| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 34 | 34 | 14 | 9 | 3.28 | .283 | 1.15 | 8.2 | 2.2 | 9.0 | 230.2 | 210 | 89 | 84 | 23 | 55 | 231 | 2 | 0 | 0 | 1 | 27 | 8 | 0 | 3.11 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 8 | 9 | 5.20 | .324 | 1.43 | 9.6 | 3.2 | 8.2 | 194.0 | 207 | 128 | 112 | 34 | 70 | 177 | 0 | 0 | 0 | 0 | 15 | 2 | 4 | 4.57 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 32 | 32 | 11 | 18 | 5.64 | .317 | 1.38 | 9.6 | 2.8 | 4.6 | 228.0 | 242 | 150 | 143 | 37 | 72 | 116 | 10 | 0 | 0 | 1 | 11 | 3 | 6 | 5.08 |
| SP | Hendrix, C.Hendrix, Claude # >> | 25 | 1914 | R | 69 | 32 | 32 | 15 | 8 | 4.52 | .320 | 1.41 | 9.4 | 3.2 | 4.5 | 225.0 | 236 | 117 | 113 | 24 | 81 | 113 | 0 | 0 | 0 | 0 | 15 | 1 | 4 | 4.48 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 95 | 0 | 8 | 5 | 3.89 | .299 | 1.26 | 7.7 | 3.7 | 8.7 | 127.1 | 108 | 59 | 55 | 5 | 52 | 123 | 0 | 10 | 7 | 0 | 0 | 3 | 11 | 2.87 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 79 | 0 | 4 | 6 | 3.69 | .305 | 1.28 | 8.9 | 2.7 | 7.6 | 95.0 | 94 | 45 | 39 | 11 | 28 | 80 | 0 | 8 | 4 | 0 | 0 | 3 | 0 | 3.80 |
| RP | Bautista, F.Bautista, Félix # >> | 28 | 2023 | R | 75 | 62 | 0 | 2 | 5 | 3.74 | .298 | 1.23 | 7.3 | 3.9 | 9.0 | 74.2 | 60 | 32 | 31 | 6 | 32 | 74 | 0 | 8 | 4 | 0 | 0 | 3 | 7 | 3.47 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 47 | 0 | 2 | 5 | 4.93 | .327 | 1.44 | 7.2 | 5.9 | 10.1 | 49.1 | 39 | 31 | 27 | 6 | 32 | 55 | 0 | 2 | 2 | 0 | 0 | 1 | 2 | 4.37 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 57 | 36 | 0 | 1 | 3 | 6.23 | .388 | 1.85 | 10.6 | 6.4 | 8.2 | 34.2 | 40 | 24 | 24 | 4 | 24 | 31 | 0 | 1 | 1 | 0 | 0 | 2 | 6 | 5.00 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 19 | 0 | 4 | 3 | 6.27 | .407 | 2.04 | 12.2 | 6.3 | 4.1 | 37.1 | 50 | 27 | 26 | 4 | 26 | 17 | 0 | 2 | 4 | 0 | 0 | 1 | 2 | 5.68 |