| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 98 | 32 | 32 | 15 | 11 | 3.60 | .274 | 1.12 | 7.9 | 2.3 | 7.9 | 244.2 | 213 | 99 | 98 | 28 | 61 | 214 | 16 | 0 | 0 | 4 | 18 | 3 | 6 | 3.52 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 81 | 31 | 31 | 8 | 15 | 5.02 | .327 | 1.44 | 9.6 | 3.3 | 4.5 | 208.0 | 222 | 129 | 116 | 32 | 77 | 103 | 5 | 0 | 0 | 1 | 13 | 4 | 1 | 5.18 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 31 | 31 | 9 | 15 | 5.83 | .367 | 1.71 | 10.6 | 4.8 | 7.6 | 185.1 | 218 | 122 | 120 | 26 | 99 | 157 | 2 | 0 | 0 | 1 | 11 | 5 | 2 | 4.82 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 30 | 30 | 14 | 10 | 4.14 | .303 | 1.27 | 8.5 | 2.9 | 4.5 | 232.1 | 219 | 114 | 107 | 31 | 75 | 115 | 13 | 0 | 0 | 3 | 12 | 9 | 3 | 4.83 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 76 | 0 | 5 | 6 | 4.62 | .336 | 1.51 | 8.6 | 5.1 | 9.0 | 89.2 | 85 | 50 | 46 | 9 | 50 | 89 | 0 | 8 | 7 | 0 | 0 | 1 | 2 | 4.03 |
| RP | Percival, T.Percival, Troy # >> | 26 | 1995 | R | 82 | 61 | 0 | 3 | 7 | 5.42 | .314 | 1.38 | 7.3 | 5.1 | 8.5 | 76.1 | 62 | 46 | 46 | 12 | 43 | 72 | 0 | 7 | 3 | 0 | 0 | 0 | 1 | 4.86 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 46 | 0 | 2 | 6 | 5.34 | .313 | 1.37 | 9.3 | 3.2 | 9.0 | 60.2 | 62 | 41 | 36 | 12 | 21 | 60 | 0 | 3 | 3 | 0 | 0 | 0 | 1 | 4.65 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 37 | 0 | 2 | 3 | 2.26 | .310 | 1.29 | 6.5 | 5.2 | 3.6 | 55.2 | 40 | 18 | 14 | 4 | 32 | 22 | 0 | 7 | 2 | 0 | 0 | 3 | 0 | 5.05 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 57 | 4 | 0 | 0 | 0 | 1.50 | .333 | 1.50 | 12.0 | 1.5 | 7.5 | 6.0 | 8 | 4 | 1 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.83 |