| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 16 | 16 | 8 | 6 | 3.27 | .257 | 1.02 | 7.2 | 2.0 | 9.2 | 113.0 | 90 | 42 | 41 | 10 | 25 | 116 | 0 | 0 | 0 | 0 | 11 | 2 | 0 | 2.81 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 15 | 15 | 4 | 8 | 5.64 | .357 | 1.64 | 11.2 | 3.6 | 5.4 | 113.1 | 141 | 72 | 71 | 15 | 45 | 68 | 3 | 0 | 0 | 0 | 5 | 3 | 3 | 4.80 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 15 | 15 | 5 | 7 | 4.94 | .332 | 1.47 | 9.6 | 3.6 | 4.6 | 102.0 | 109 | 64 | 56 | 14 | 41 | 52 | 0 | 0 | 0 | 0 | 6 | 2 | 2 | 5.03 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 44 | 0 | 2 | 2 | 3.58 | .255 | 1.03 | 7.1 | 2.3 | 9.3 | 60.1 | 47 | 28 | 24 | 5 | 15 | 62 | 0 | 8 | 2 | 0 | 0 | 0 | 2 | 2.77 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 36 | 0 | 5 | 0 | 2.45 | .271 | 1.12 | 6.8 | 3.4 | 9.0 | 40.1 | 30 | 11 | 11 | 1 | 15 | 40 | 0 | 8 | 3 | 0 | 0 | 0 | 0 | 2.45 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 23 | 0 | 1 | 1 | 4.26 | .321 | 1.42 | 9.9 | 2.8 | 8.5 | 19.0 | 21 | 9 | 9 | 5 | 6 | 18 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 5.47 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 16 | 0 | 1 | 0 | 9.82 | .450 | 2.39 | 13.5 | 9.0 | 10.9 | 14.2 | 21 | 16 | 16 | 1 | 14 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 4.71 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 4 | 0 | 2 | 0 | 0.00 | .125 | 0.43 | 0.0 | 4.5 | 15.8 | 4.2 | 0 | 0 | 0 | 0 | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1.00 |