| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 32 | 32 | 11 | 12 | 4.18 | .290 | 1.20 | 8.0 | 2.8 | 9.2 | 209.0 | 185 | 99 | 97 | 22 | 66 | 213 | 0 | 0 | 0 | 0 | 20 | 5 | 0 | 3.35 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 72 | 31 | 31 | 11 | 12 | 4.19 | .305 | 1.30 | 8.9 | 2.9 | 4.9 | 217.0 | 214 | 106 | 101 | 20 | 69 | 117 | 2 | 0 | 0 | 1 | 19 | 3 | 4 | 4.12 |
| SP | Tudor, J.Tudor, John # >> | 31 | 1985 | L | 64 | 31 | 31 | 11 | 15 | 4.58 | .316 | 1.37 | 9.7 | 2.6 | 5.0 | 224.0 | 241 | 120 | 114 | 25 | 65 | 124 | 4 | 0 | 0 | 2 | 14 | 4 | 2 | 4.27 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 30 | 30 | 8 | 13 | 4.67 | .324 | 1.40 | 8.5 | 4.1 | 4.3 | 181.0 | 170 | 97 | 94 | 16 | 83 | 86 | 0 | 0 | 0 | 0 | 15 | 7 | 3 | 4.69 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 89 | 0 | 9 | 5 | 3.17 | .301 | 1.25 | 7.3 | 4.0 | 7.5 | 113.2 | 92 | 50 | 40 | 12 | 50 | 94 | 0 | 11 | 8 | 0 | 0 | 5 | 4 | 4.18 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 64 | 0 | 2 | 4 | 3.67 | .285 | 1.18 | 6.8 | 4.0 | 7.8 | 68.2 | 51 | 28 | 28 | 8 | 30 | 59 | 0 | 15 | 2 | 0 | 0 | 1 | 7 | 4.16 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 44 | 0 | 2 | 4 | 5.59 | .358 | 1.63 | 8.3 | 6.6 | 8.6 | 48.1 | 44 | 30 | 30 | 4 | 35 | 46 | 0 | 4 | 1 | 0 | 0 | 2 | 3 | 4.48 |
| RP | Russell, J.Russell, Jeff >> | 28 | 1989 | R | 56 | 34 | 0 | 2 | 0 | 2.37 | .301 | 1.26 | 7.6 | 3.8 | 7.3 | 38.0 | 32 | 10 | 10 | 3 | 16 | 31 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 3.74 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 15 | 0 | 1 | 4 | 5.40 | .402 | 1.96 | 11.5 | 6.5 | 9.5 | 18.1 | 23 | 11 | 11 | 3 | 13 | 19 | 0 | 3 | 1 | 0 | 0 | 1 | 1 | 5.39 |