| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 25 | 25 | 13 | 5 | 2.04 | .238 | 0.92 | 5.7 | 2.6 | 8.9 | 181.0 | 115 | 41 | 41 | 9 | 52 | 178 | 3 | 0 | 0 | 1 | 22 | 3 | 0 | 2.59 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 80 | 24 | 24 | 9 | 8 | 5.16 | .301 | 1.29 | 9.0 | 2.6 | 9.1 | 129.0 | 129 | 76 | 74 | 22 | 37 | 130 | 2 | 0 | 0 | 1 | 10 | 1 | 5 | 4.09 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 22 | 22 | 9 | 9 | 3.81 | .293 | 1.22 | 8.4 | 2.7 | 8.4 | 146.1 | 136 | 71 | 62 | 20 | 43 | 136 | 3 | 0 | 0 | 1 | 14 | 3 | 2 | 3.86 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 23 | 23 | 9 | 8 | 4.17 | .309 | 1.32 | 7.7 | 4.2 | 6.8 | 140.1 | 119 | 66 | 65 | 14 | 66 | 105 | 2 | 0 | 0 | 1 | 12 | 3 | 2 | 4.28 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 67 | 0 | 5 | 2 | 3.54 | .297 | 1.24 | 6.7 | 4.4 | 10.0 | 89.0 | 66 | 35 | 35 | 9 | 44 | 99 | 0 | 4 | 5 | 0 | 0 | 3 | 9 | 3.67 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 46 | 0 | 3 | 3 | 3.75 | .313 | 1.32 | 8.7 | 3.2 | 6.8 | 60.0 | 58 | 26 | 25 | 9 | 21 | 45 | 0 | 6 | 3 | 0 | 0 | 3 | 0 | 4.65 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 39 | 0 | 2 | 3 | 1.63 | .270 | 1.07 | 5.9 | 3.9 | 9.6 | 49.2 | 32 | 9 | 9 | 3 | 21 | 52 | 0 | 5 | 1 | 0 | 0 | 2 | 1 | 3.08 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 28 | 0 | 3 | 3 | 4.24 | .339 | 1.51 | 9.5 | 4.3 | 3.4 | 40.1 | 42 | 22 | 19 | 6 | 19 | 15 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 5.70 |