| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 34 | 34 | 15 | 9 | 3.22 | .275 | 1.12 | 7.8 | 2.3 | 8.0 | 226.2 | 196 | 95 | 81 | 25 | 58 | 200 | 4 | 0 | 0 | 1 | 23 | 4 | 3 | 3.49 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 91 | 35 | 35 | 13 | 9 | 4.24 | .300 | 1.25 | 8.3 | 3.0 | 9.1 | 204.0 | 188 | 100 | 96 | 21 | 68 | 206 | 1 | 0 | 0 | 1 | 19 | 6 | 5 | 3.41 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 32 | 32 | 17 | 9 | 3.28 | .270 | 1.08 | 8.0 | 1.7 | 6.0 | 225.0 | 201 | 89 | 82 | 19 | 42 | 150 | 13 | 0 | 0 | 2 | 19 | 7 | 5 | 3.42 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 32 | 32 | 10 | 11 | 3.96 | .313 | 1.35 | 8.8 | 3.3 | 7.7 | 206.2 | 202 | 95 | 91 | 15 | 76 | 176 | 3 | 0 | 0 | 0 | 18 | 4 | 2 | 3.40 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 73 | 31 | 31 | 13 | 4 | 4.62 | .305 | 1.30 | 8.7 | 3.0 | 4.4 | 192.2 | 186 | 107 | 99 | 17 | 65 | 93 | 3 | 0 | 0 | 0 | 14 | 3 | 5 | 4.24 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 87 | 0 | 10 | 3 | 2.66 | .269 | 1.06 | 5.9 | 3.7 | 9.6 | 132.0 | 86 | 46 | 39 | 13 | 54 | 141 | 0 | 14 | 5 | 0 | 0 | 6 | 0 | 3.51 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 66 | 0 | 5 | 3 | 2.63 | .256 | 1.02 | 5.6 | 3.6 | 9.5 | 89.0 | 55 | 26 | 26 | 10 | 36 | 94 | 0 | 8 | 3 | 0 | 0 | 1 | 0 | 3.60 |
| RP | Saito, T.Saito, Takashi † >> | 37 | 2007 | R | 91 | 56 | 0 | 10 | 1 | 1.40 | .249 | 1.00 | 6.1 | 2.9 | 6.8 | 77.1 | 52 | 13 | 12 | 4 | 25 | 58 | 0 | 7 | 2 | 0 | 0 | 0 | 0 | 3.14 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 49 | 0 | 3 | 5 | 4.14 | .290 | 1.23 | 9.6 | 1.6 | 7.9 | 58.2 | 62 | 30 | 27 | 6 | 10 | 51 | 0 | 7 | 6 | 0 | 0 | 0 | 0 | 3.10 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 33 | 0 | 4 | 4 | 6.03 | .343 | 1.56 | 9.6 | 4.6 | 10.2 | 31.1 | 33 | 22 | 21 | 3 | 16 | 35 | 0 | 3 | 2 | 0 | 0 | 0 | 3 | 3.55 |
| SP | Darvish, Y.Darvish, Yu >> | 35 | 2022 | R | 64 | 10 | 0 | 1 | 2 | 6.94 | .397 | 1.89 | 15.5 | 2.5 | 7.4 | 11.2 | 19 | 10 | 9 | 3 | 3 | 9 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 6.00 |