| SP | Tiant, L.Tiant, Luis $ >> | 28 | 1968 | R | 97 | 37 | 37 | 18 | 11 | 4.99 | .327 | 1.44 | 8.7 | 4.3 | 7.4 | 232.2 | 225 | 134 | 129 | 36 | 110 | 190 | 2 | 0 | 0 | 0 | 19 | 4 | 5 | 4.85 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 37 | 37 | 8 | 16 | 4.80 | .301 | 1.26 | 8.8 | 2.6 | 8.3 | 253.1 | 246 | 140 | 135 | 40 | 74 | 233 | 5 | 0 | 0 | 2 | 16 | 8 | 7 | 4.19 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 34 | 34 | 17 | 13 | 4.24 | .295 | 1.24 | 9.2 | 2.0 | 8.3 | 235.2 | 241 | 118 | 111 | 38 | 52 | 218 | 4 | 0 | 0 | 0 | 17 | 3 | 2 | 3.95 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 32 | 32 | 16 | 13 | 4.41 | .313 | 1.34 | 8.2 | 3.9 | 4.6 | 218.1 | 198 | 109 | 107 | 19 | 95 | 112 | 5 | 0 | 0 | 1 | 16 | 5 | 4 | 4.48 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 97 | 70 | 0 | 5 | 7 | 3.44 | .287 | 1.18 | 7.8 | 2.8 | 9.1 | 68.0 | 59 | 28 | 26 | 5 | 21 | 69 | 0 | 45 | 5 | 0 | 0 | 2 | 1 | 2.94 |
| SU | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 52 | 0 | 1 | 2 | 2.29 | .283 | 1.15 | 6.4 | 3.9 | 6.5 | 55.0 | 39 | 15 | 14 | 2 | 24 | 40 | 0 | 10 | 2 | 0 | 0 | 2 | 1 | 3.44 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 76 | 43 | 0 | 4 | 2 | 5.10 | .359 | 1.65 | 9.9 | 5.1 | 7.9 | 42.1 | 46 | 30 | 24 | 6 | 24 | 37 | 0 | 0 | 1 | 0 | 0 | 1 | 4 | 4.88 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 67 | 31 | 0 | 3 | 1 | 2.13 | .333 | 1.46 | 9.0 | 4.3 | 9.0 | 25.1 | 25 | 9 | 6 | 2 | 12 | 25 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3.60 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 27 | 1 | 2 | 3 | 4.71 | .335 | 1.51 | 9.8 | 3.9 | 3.7 | 112.2 | 122 | 59 | 59 | 16 | 48 | 46 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 5.32 |