| SP | Koufax, S.Koufax, Sandy # >> | 30 | 1965 | L | 98 | 25 | 25 | 9 | 11 | 3.73 | .282 | 1.16 | 7.8 | 2.6 | 9.4 | 188.1 | 163 | 80 | 78 | 13 | 55 | 196 | 9 | 0 | 0 | 1 | 14 | 4 | 3 | 2.76 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 79 | 22 | 22 | 4 | 11 | 7.99 | .379 | 1.80 | 13.0 | 3.3 | 9.2 | 112.2 | 162 | 105 | 100 | 23 | 41 | 114 | 0 | 0 | 0 | 0 | 5 | 3 | 8 | 4.81 |
| SP | Schmidt, J.Schmidt, Jason † >> | 30 | 2003 | R | 68 | 24 | 24 | 13 | 8 | 4.24 | .316 | 1.36 | 8.5 | 3.7 | 7.3 | 155.0 | 147 | 82 | 73 | 19 | 64 | 126 | 4 | 0 | 0 | 4 | 13 | 4 | 2 | 4.28 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 23 | 23 | 11 | 8 | 3.56 | .306 | 1.32 | 8.5 | 3.4 | 5.5 | 159.1 | 151 | 69 | 63 | 11 | 60 | 98 | 5 | 0 | 0 | 0 | 16 | 0 | 3 | 3.80 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 21 | 21 | 8 | 9 | 5.75 | .344 | 1.56 | 9.6 | 4.4 | 4.2 | 122.0 | 130 | 79 | 78 | 21 | 60 | 57 | 2 | 0 | 0 | 1 | 8 | 2 | 2 | 5.83 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 56 | 0 | 6 | 1 | 1.52 | .232 | 0.87 | 4.5 | 3.4 | 8.6 | 82.2 | 41 | 16 | 14 | 3 | 31 | 78 | 0 | 4 | 1 | 0 | 0 | 3 | 0 | 2.82 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 53 | 0 | 2 | 4 | 4.23 | .312 | 1.35 | 8.7 | 3.5 | 9.6 | 61.2 | 59 | 29 | 29 | 8 | 24 | 65 | 0 | 6 | 3 | 0 | 0 | 1 | 4 | 3.80 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 41 | 0 | 1 | 0 | 3.23 | .264 | 1.08 | 7.3 | 2.4 | 4.2 | 53.0 | 43 | 19 | 19 | 5 | 14 | 25 | 0 | 6 | 2 | 0 | 0 | 0 | 1 | 4.08 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 33 | 0 | 4 | 0 | 2.63 | .252 | 1.01 | 5.7 | 3.4 | 3.8 | 68.1 | 43 | 21 | 20 | 4 | 26 | 29 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 4.06 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 51 | 5 | 2 | 1 | 1 | 2.89 | .356 | 1.55 | 8.5 | 6.0 | 4.5 | 18.2 | 17 | 8 | 6 | 0 | 12 | 9 | 0 | 1 | 0 | 0 | 2 | 2 | 0 | 4.33 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 12 | 1 | 4 | 2 | 5.65 | .338 | 1.50 | 10.0 | 3.9 | 4.8 | 28.2 | 31 | 19 | 18 | 4 | 12 | 15 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 5.18 |