| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 34 | 34 | 11 | 12 | 3.32 | .275 | 1.12 | 7.4 | 2.6 | 9.6 | 211.1 | 174 | 81 | 78 | 21 | 62 | 225 | 1 | 0 | 0 | 0 | 23 | 5 | 0 | 3.11 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 79 | 33 | 32 | 11 | 13 | 5.63 | .327 | 1.43 | 10.3 | 2.6 | 5.2 | 179.0 | 204 | 122 | 112 | 26 | 52 | 104 | 2 | 0 | 0 | 1 | 12 | 5 | 5 | 4.68 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 33 | 32 | 9 | 14 | 4.69 | .301 | 1.28 | 8.6 | 3.0 | 5.1 | 180.1 | 171 | 95 | 94 | 24 | 60 | 101 | 1 | 0 | 0 | 0 | 18 | 2 | 0 | 4.64 |
| SP | Spahn, W.Spahn, Warren >> | 32 | 1953 | L | 20 | 35 | 30 | 10 | 13 | 5.87 | .327 | 1.46 | 9.8 | 3.4 | 5.0 | 178.0 | 193 | 117 | 116 | 26 | 67 | 98 | 1 | 0 | 0 | 0 | 9 | 0 | 3 | 4.93 |
| RP | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 94 | 92 | 0 | 7 | 5 | 3.98 | .318 | 1.37 | 8.0 | 4.4 | 9.9 | 113.0 | 100 | 52 | 50 | 12 | 55 | 124 | 0 | 1 | 2 | 0 | 0 | 3 | 2 | 3.73 |
| CL | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 94 | 84 | 0 | 3 | 5 | 3.89 | .292 | 1.23 | 7.0 | 4.1 | 11.6 | 88.0 | 68 | 38 | 38 | 5 | 40 | 113 | 0 | 35 | 4 | 0 | 0 | 1 | 0 | 2.57 |
| SU | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 75 | 0 | 2 | 2 | 4.08 | .316 | 1.36 | 9.6 | 2.6 | 8.4 | 86.0 | 92 | 40 | 39 | 10 | 25 | 80 | 0 | 2 | 2 | 0 | 0 | 2 | 0 | 3.59 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 77 | 0 | 5 | 0 | 2.68 | .298 | 1.25 | 7.2 | 4.0 | 8.2 | 87.1 | 70 | 31 | 26 | 5 | 39 | 79 | 0 | 2 | 0 | 0 | 0 | 2 | 4 | 3.34 |
| RP | Arroyo, L.Arroyo, Luis >> | 34 | 1961 | L | 13 | 81 | 0 | 6 | 7 | 5.80 | .342 | 1.52 | 8.4 | 5.3 | 5.9 | 113.1 | 105 | 74 | 73 | 20 | 67 | 74 | 0 | 0 | 2 | 0 | 0 | 5 | 8 | 5.90 |