| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 27 | 27 | 11 | 8 | 3.17 | .274 | 1.09 | 7.6 | 2.3 | 10.7 | 176.0 | 148 | 66 | 62 | 20 | 44 | 209 | 0 | 0 | 0 | 0 | 16 | 7 | 0 | 2.97 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 26 | 26 | 9 | 8 | 3.66 | .302 | 1.27 | 7.5 | 3.9 | 8.4 | 172.0 | 144 | 72 | 70 | 20 | 74 | 160 | 0 | 0 | 0 | 0 | 17 | 5 | 1 | 4.03 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 80 | 25 | 25 | 4 | 13 | 5.93 | .346 | 1.54 | 9.9 | 4.0 | 8.9 | 139.2 | 153 | 96 | 92 | 16 | 62 | 138 | 0 | 0 | 0 | 0 | 10 | 7 | 7 | 4.00 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 25 | 25 | 10 | 8 | 3.02 | .238 | 0.90 | 6.4 | 1.7 | 5.4 | 178.2 | 127 | 62 | 60 | 17 | 33 | 106 | 9 | 0 | 0 | 1 | 19 | 7 | 4 | 3.72 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 61 | 0 | 9 | 7 | 3.78 | .283 | 1.13 | 6.5 | 3.7 | 8.7 | 66.2 | 48 | 31 | 28 | 9 | 27 | 64 | 0 | 25 | 4 | 0 | 0 | 4 | 1 | 4.24 |
| SU | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 64 | 0 | 1 | 6 | 5.15 | .331 | 1.43 | 9.7 | 3.2 | 7.4 | 73.1 | 79 | 42 | 42 | 9 | 26 | 60 | 0 | 1 | 7 | 0 | 0 | 4 | 7 | 4.19 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 70 | 0 | 0 | 2 | 2.16 | .273 | 1.08 | 6.7 | 3.1 | 8.5 | 66.2 | 49 | 16 | 16 | 4 | 23 | 62 | 0 | 2 | 1 | 0 | 0 | 3 | 2 | 3.09 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 62 | 0 | 4 | 2 | 3.56 | .281 | 1.17 | 6.6 | 4.0 | 9.3 | 65.2 | 48 | 27 | 26 | 11 | 29 | 67 | 0 | 2 | 1 | 0 | 0 | 0 | 3 | 4.48 |
| RP | Gossage, R.Gossage, Rich # >> | 30 | 1981 | R | 90 | 60 | 0 | 5 | 3 | 6.75 | .379 | 1.77 | 11.0 | 5.2 | 8.3 | 54.2 | 66 | 45 | 41 | 9 | 31 | 50 | 0 | 2 | 5 | 0 | 0 | 3 | 1 | 5.20 |