| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 11 | 11 | 7 | 3 | 2.90 | .282 | 1.17 | 7.7 | 2.9 | 7.5 | 80.2 | 68 | 28 | 26 | 11 | 26 | 67 | 2 | 0 | 0 | 1 | 8 | 1 | 1 | 4.13 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 84 | 11 | 11 | 2 | 5 | 5.27 | .337 | 1.53 | 10.6 | 3.2 | 6.1 | 56.1 | 66 | 36 | 33 | 8 | 20 | 38 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4.57 |
| SP | Hernandez, F.Hernandez, Felix # >> | 28 | 2014 | R | 79 | 11 | 11 | 5 | 3 | 5.40 | .331 | 1.47 | 10.7 | 2.6 | 9.0 | 63.1 | 75 | 39 | 38 | 7 | 18 | 63 | 1 | 0 | 0 | 0 | 4 | 1 | 2 | 3.35 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 10 | 10 | 3 | 4 | 6.92 | .347 | 1.58 | 11.0 | 3.2 | 7.3 | 53.1 | 65 | 42 | 41 | 12 | 19 | 43 | 0 | 0 | 0 | 0 | 3 | 1 | 3 | 5.45 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 27 | 0 | 1 | 2 | 3.53 | .282 | 1.15 | 7.7 | 2.8 | 8.5 | 35.2 | 30 | 14 | 14 | 2 | 11 | 33 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 2.89 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 26 | 0 | 1 | 0 | 3.27 | .272 | 1.12 | 6.8 | 3.3 | 9.3 | 33.0 | 25 | 12 | 12 | 3 | 12 | 34 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 3.21 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 26 | 0 | 2 | 0 | 5.86 | .308 | 1.34 | 8.7 | 3.7 | 9.3 | 27.2 | 26 | 18 | 18 | 5 | 11 | 28 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 4.56 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 18 | 0 | 1 | 0 | 1.17 | .216 | 0.83 | 3.5 | 3.9 | 7.4 | 23.0 | 9 | 3 | 3 | 1 | 10 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.22 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 6 | 0 | 0 | 2 | 6.52 | .370 | 1.76 | 10.0 | 7.0 | 8.0 | 9.2 | 10 | 7 | 7 | 3 | 7 | 8 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 7.89 |