| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 27 | 27 | 8 | 15 | 3.98 | .285 | 1.17 | 8.5 | 2.1 | 7.3 | 196.2 | 186 | 94 | 87 | 25 | 45 | 159 | 8 | 0 | 0 | 2 | 17 | 4 | 2 | 3.79 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 26 | 26 | 6 | 15 | 4.50 | .301 | 1.27 | 9.0 | 2.5 | 5.7 | 186.0 | 185 | 99 | 93 | 20 | 51 | 117 | 3 | 0 | 0 | 0 | 9 | 4 | 3 | 4.03 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 26 | 26 | 5 | 14 | 5.56 | .332 | 1.49 | 10.4 | 3.0 | 8.5 | 144.0 | 166 | 95 | 89 | 23 | 48 | 136 | 0 | 0 | 0 | 0 | 10 | 1 | 4 | 4.21 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 26 | 26 | 6 | 13 | 5.02 | .330 | 1.46 | 10.0 | 3.2 | 6.8 | 174.0 | 193 | 101 | 97 | 25 | 61 | 131 | 3 | 0 | 0 | 1 | 12 | 3 | 2 | 4.47 |
| SP | Hendrix, C.Hendrix, Claude >> | 25 | 1914 | R | 69 | 24 | 24 | 7 | 11 | 3.95 | .293 | 1.23 | 8.3 | 2.8 | 4.4 | 166.1 | 153 | 79 | 73 | 20 | 51 | 82 | 5 | 0 | 0 | 2 | 13 | 3 | 4 | 4.55 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 71 | 0 | 7 | 4 | 2.42 | .241 | 0.93 | 5.6 | 2.8 | 7.3 | 96.2 | 60 | 27 | 26 | 6 | 30 | 78 | 0 | 8 | 4 | 0 | 0 | 2 | 5 | 3.19 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 42 | 0 | 4 | 0 | 2.91 | .245 | 0.94 | 6.4 | 2.2 | 9.6 | 58.2 | 41 | 19 | 19 | 7 | 14 | 62 | 0 | 7 | 2 | 0 | 0 | 2 | 0 | 3.26 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 25 | 0 | 4 | 0 | 5.47 | .313 | 1.37 | 7.6 | 4.8 | 8.7 | 26.1 | 22 | 16 | 16 | 3 | 14 | 25 | 0 | 2 | 0 | 0 | 0 | 0 | 3 | 4.19 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 16 | 0 | 1 | 0 | 0.90 | .211 | 0.75 | 4.1 | 2.7 | 5.9 | 20.0 | 9 | 3 | 2 | 2 | 6 | 13 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.05 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 16 | 0 | 1 | 0 | 6.50 | .341 | 1.56 | 10.0 | 4.0 | 12.5 | 18.0 | 20 | 13 | 13 | 2 | 8 | 25 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.00 |