| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 11 | 11 | 4 | 3 | 3.97 | .316 | 1.37 | 9.9 | 2.5 | 9.7 | 79.1 | 87 | 36 | 35 | 11 | 22 | 85 | 0 | 0 | 0 | 0 | 6 | 1 | 1 | 3.53 |
| SP | Tiant, L.Tiant, Luis # >> | 28 | 1968 | R | 97 | 11 | 11 | 5 | 4 | 4.12 | .312 | 1.35 | 8.7 | 3.6 | 7.7 | 78.2 | 75 | 40 | 36 | 7 | 31 | 67 | 1 | 0 | 0 | 0 | 6 | 1 | 0 | 3.68 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 9 | 9 | 2 | 3 | 3.29 | .311 | 1.30 | 7.2 | 4.7 | 8.7 | 54.2 | 43 | 20 | 20 | 4 | 28 | 52 | 0 | 0 | 0 | 0 | 6 | 3 | 1 | 3.76 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 11 | 11 | 4 | 4 | 4.22 | .293 | 1.23 | 7.7 | 3.3 | 8.9 | 79.0 | 68 | 37 | 37 | 10 | 29 | 78 | 2 | 0 | 0 | 0 | 4 | 1 | 0 | 3.81 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 29 | 0 | 5 | 2 | 3.45 | .277 | 1.11 | 7.0 | 3.1 | 9.8 | 44.1 | 34 | 17 | 17 | 6 | 15 | 48 | 0 | 4 | 2 | 0 | 0 | 2 | 1 | 3.75 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 12 | 0 | 0 | 0 | 4.15 | .339 | 1.46 | 10.4 | 2.8 | 6.9 | 13.0 | 15 | 6 | 6 | 3 | 4 | 10 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.62 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 76 | 9 | 0 | 2 | 1 | 0.75 | .200 | 0.67 | 3.8 | 2.3 | 9.0 | 12.0 | 5 | 1 | 1 | 1 | 3 | 12 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.08 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 7 | 0 | 1 | 0 | 4.32 | .324 | 1.44 | 11.3 | 2.3 | 9.0 | 8.1 | 10 | 4 | 4 | 2 | 2 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.00 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 4 | 2 | 2 | 1 | 6.94 | .407 | 2.06 | 16.4 | 3.3 | 2.5 | 11.2 | 20 | 10 | 9 | 2 | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.91 |