| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 27 | 27 | 12 | 7 | 3.53 | .308 | 1.31 | 7.6 | 4.2 | 8.1 | 155.2 | 131 | 71 | 61 | 11 | 73 | 140 | 0 | 0 | 0 | 0 | 14 | 4 | 0 | 3.61 |
| SP | Snell, B.Snell, Blake † >> | 25 | 2018 | L | 80 | 26 | 26 | 13 | 5 | 3.53 | .313 | 1.34 | 7.0 | 5.1 | 7.1 | 147.2 | 115 | 59 | 58 | 15 | 83 | 116 | 0 | 0 | 0 | 0 | 12 | 4 | 8 | 4.52 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 26 | 26 | 12 | 6 | 4.34 | .282 | 1.17 | 8.8 | 1.7 | 4.6 | 172.0 | 169 | 84 | 83 | 17 | 33 | 87 | 6 | 0 | 0 | 1 | 13 | 1 | 4 | 3.87 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 77 | 26 | 26 | 11 | 9 | 3.81 | .289 | 1.19 | 8.3 | 2.5 | 5.7 | 182.0 | 167 | 85 | 77 | 19 | 50 | 115 | 5 | 0 | 0 | 1 | 14 | 5 | 2 | 4.00 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 27 | 24 | 8 | 6 | 5.27 | .351 | 1.60 | 9.3 | 5.2 | 7.3 | 136.2 | 140 | 85 | 80 | 17 | 78 | 110 | 0 | 1 | 0 | 0 | 10 | 4 | 2 | 4.82 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 78 | 0 | 8 | 6 | 3.49 | .326 | 1.44 | 6.4 | 6.6 | 8.1 | 90.1 | 64 | 39 | 35 | 3 | 66 | 81 | 0 | 6 | 3 | 0 | 0 | 1 | 6 | 3.87 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 66 | 0 | 5 | 2 | 3.57 | .305 | 1.28 | 7.5 | 4.1 | 8.0 | 85.2 | 71 | 35 | 34 | 5 | 39 | 76 | 0 | 5 | 4 | 0 | 0 | 3 | 9 | 3.46 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 56 | 0 | 5 | 4 | 3.88 | .308 | 1.34 | 7.7 | 4.4 | 6.6 | 67.1 | 57 | 33 | 29 | 7 | 33 | 49 | 0 | 9 | 1 | 0 | 0 | 0 | 0 | 4.37 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 48 | 0 | 2 | 2 | 3.02 | .318 | 1.40 | 6.8 | 5.9 | 7.6 | 53.2 | 40 | 24 | 18 | 5 | 35 | 45 | 0 | 9 | 3 | 0 | 0 | 0 | 0 | 4.51 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 45 | 0 | 4 | 2 | 3.39 | .325 | 1.40 | 7.6 | 5.0 | 6.3 | 66.1 | 56 | 36 | 25 | 6 | 37 | 46 | 0 | 5 | 2 | 0 | 0 | 3 | 2 | 4.61 |