| SP | Arrieta, J.Arrieta, Jake † # >> | 29 | 2015 | R | 92 | 20 | 20 | 11 | 5 | 2.18 | .244 | 0.96 | 6.9 | 1.8 | 7.5 | 152.2 | 116 | 41 | 37 | 11 | 31 | 126 | 2 | 0 | 0 | 2 | 17 | 1 | 3 | 2.91 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 20 | 20 | 8 | 2 | 2.60 | .270 | 1.09 | 7.3 | 2.5 | 4.9 | 138.2 | 112 | 40 | 40 | 15 | 39 | 75 | 1 | 0 | 0 | 0 | 15 | 3 | 0 | 4.24 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 19 | 19 | 13 | 2 | 1.88 | .240 | 0.92 | 6.3 | 2.1 | 5.5 | 148.2 | 103 | 31 | 31 | 4 | 34 | 91 | 3 | 0 | 0 | 2 | 17 | 4 | 2 | 2.89 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 19 | 19 | 10 | 5 | 3.44 | .301 | 1.28 | 8.3 | 3.2 | 6.3 | 123.0 | 113 | 60 | 47 | 12 | 44 | 86 | 0 | 0 | 0 | 0 | 12 | 2 | 4 | 3.99 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 50 | 0 | 4 | 4 | 3.05 | .253 | 0.98 | 7.0 | 1.8 | 8.8 | 59.0 | 46 | 24 | 20 | 4 | 12 | 58 | 0 | 4 | 2 | 0 | 0 | 2 | 0 | 2.63 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 37 | 0 | 4 | 3 | 3.23 | .304 | 1.28 | 7.6 | 3.9 | 9.7 | 39.0 | 33 | 15 | 14 | 3 | 17 | 42 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 3.23 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 18 | 0 | 2 | 2 | 7.71 | .380 | 1.84 | 8.4 | 8.4 | 7.9 | 16.1 | 15 | 14 | 14 | 3 | 15 | 14 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 6.50 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 18 | 0 | 1 | 1 | 0.89 | .218 | 0.84 | 3.6 | 4.1 | 5.0 | 20.1 | 8 | 2 | 2 | 0 | 9 | 11 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 3.25 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 3 | 0 | 0 | 0 | 3.00 | .308 | 1.33 | 7.0 | 5.0 | 6.0 | 9.0 | 7 | 4 | 3 | 0 | 5 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.33 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 96 | 38 | 0 | 0 | 1 | 1.87 | .241 | 0.92 | 4.9 | 3.5 | 8.7 | 33.2 | 18 | 7 | 7 | 2 | 13 | 32 | 0 | 32 | 2 | 0 | 0 | 1 | 3 | 3.12 |