| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 34 | 34 | 13 | 15 | 2.95 | .271 | 1.09 | 8.6 | 1.2 | 7.6 | 250.1 | 238 | 86 | 82 | 25 | 34 | 211 | 14 | 0 | 0 | 2 | 25 | 7 | 3 | 3.10 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 33 | 33 | 6 | 11 | 4.98 | .326 | 1.41 | 9.4 | 3.2 | 4.1 | 161.0 | 169 | 90 | 89 | 24 | 58 | 74 | 0 | 0 | 0 | 0 | 10 | 7 | 2 | 5.23 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 32 | 32 | 10 | 17 | 4.72 | .310 | 1.33 | 8.4 | 3.6 | 5.8 | 207.2 | 193 | 119 | 109 | 19 | 83 | 133 | 9 | 0 | 0 | 2 | 12 | 4 | 12 | 4.17 |
| SP | Coveleski, S.Coveleski, Stan # >> | 28 | 1917 | R | 62 | 31 | 31 | 7 | 16 | 5.13 | .336 | 1.49 | 10.0 | 3.5 | 5.1 | 168.1 | 186 | 102 | 96 | 21 | 65 | 96 | 0 | 0 | 0 | 0 | 15 | 4 | 2 | 4.71 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 76 | 0 | 3 | 3 | 4.41 | .327 | 1.43 | 9.9 | 3.0 | 7.6 | 100.0 | 110 | 53 | 49 | 12 | 33 | 84 | 0 | 2 | 6 | 0 | 0 | 3 | 4 | 3.96 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 70 | 0 | 4 | 1 | 3.95 | .295 | 1.23 | 8.9 | 2.3 | 7.4 | 95.2 | 94 | 43 | 42 | 13 | 24 | 78 | 0 | 8 | 2 | 0 | 0 | 2 | 2 | 3.96 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 68 | 68 | 0 | 9 | 8 | 4.06 | .313 | 1.35 | 8.3 | 3.8 | 5.5 | 122.0 | 113 | 57 | 55 | 16 | 52 | 74 | 0 | 6 | 4 | 0 | 0 | 2 | 8 | 4.82 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 47 | 0 | 2 | 6 | 4.82 | .275 | 1.12 | 8.6 | 1.6 | 7.7 | 61.2 | 58 | 35 | 33 | 8 | 11 | 52 | 0 | 4 | 2 | 0 | 0 | 1 | 3 | 3.59 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 5 | 0 | 1 | 0 | 4.82 | .404 | 2.04 | 13.0 | 6.0 | 9.0 | 9.1 | 13 | 5 | 5 | 0 | 6 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.00 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 34 | 0 | 1 | 3 | 5.40 | .386 | 1.86 | 12.6 | 4.1 | 6.0 | 70.0 | 98 | 47 | 42 | 10 | 32 | 47 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 4.97 |