| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 32 | 32 | 11 | 18 | 5.55 | .340 | 1.54 | 10.3 | 3.5 | 8.4 | 204.1 | 234 | 134 | 126 | 31 | 80 | 191 | 0 | 0 | 0 | 0 | 13 | 2 | 5 | 4.31 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 6 | 16 | 4.97 | .318 | 1.37 | 9.0 | 3.4 | 8.0 | 199.1 | 198 | 111 | 110 | 27 | 75 | 176 | 0 | 0 | 0 | 0 | 14 | 6 | 4 | 4.22 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 32 | 32 | 12 | 13 | 4.79 | .311 | 1.35 | 9.0 | 3.2 | 6.9 | 225.2 | 224 | 125 | 120 | 32 | 81 | 172 | 5 | 0 | 0 | 1 | 16 | 1 | 3 | 4.41 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 32 | 32 | 13 | 8 | 4.20 | .309 | 1.33 | 8.9 | 3.1 | 5.1 | 203.2 | 201 | 98 | 95 | 21 | 70 | 116 | 1 | 0 | 0 | 0 | 21 | 2 | 1 | 4.27 |
| SP | Tudor, J.Tudor, John # >> | 31 | 1985 | L | 63 | 31 | 31 | 9 | 17 | 5.31 | .316 | 1.37 | 9.7 | 2.7 | 5.2 | 210.1 | 226 | 126 | 124 | 25 | 62 | 122 | 6 | 0 | 0 | 2 | 15 | 3 | 3 | 4.31 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 87 | 0 | 3 | 6 | 4.53 | .280 | 1.11 | 8.1 | 1.9 | 7.3 | 111.1 | 100 | 57 | 56 | 9 | 24 | 90 | 0 | 10 | 7 | 0 | 0 | 6 | 0 | 3.24 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 89 | 87 | 0 | 1 | 5 | 3.57 | .300 | 1.27 | 7.5 | 4.0 | 8.1 | 106.0 | 88 | 48 | 42 | 11 | 47 | 95 | 0 | 7 | 3 | 0 | 0 | 1 | 2 | 3.92 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 71 | 0 | 4 | 4 | 2.00 | .292 | 1.23 | 6.4 | 4.7 | 8.3 | 81.0 | 58 | 20 | 18 | 5 | 42 | 75 | 0 | 7 | 2 | 0 | 0 | 0 | 2 | 3.51 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 62 | 50 | 0 | 1 | 4 | 6.14 | .347 | 1.55 | 8.1 | 6.0 | 10.5 | 48.1 | 43 | 35 | 33 | 6 | 32 | 56 | 0 | 4 | 1 | 0 | 0 | 2 | 4 | 4.42 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 5 | 2 | 1 | 1 | 5.63 | .342 | 1.56 | 9.6 | 4.5 | 6.8 | 16.0 | 17 | 10 | 10 | 4 | 8 | 12 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 6.25 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 60 | 26 | 0 | 1 | 7 | 6.95 | .379 | 1.81 | 9.6 | 6.8 | 4.2 | 45.1 | 48 | 36 | 35 | 9 | 34 | 21 | 0 | 2 | 2 | 0 | 0 | 1 | 6 | 7.00 |