| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 4 | 4 | 1 | 2 | 3.21 | .236 | 0.89 | 6.1 | 1.9 | 10.3 | 28.0 | 19 | 10 | 10 | 1 | 6 | 32 | 0 | 0 | 0 | 0 | 3 | 1 | 0 | 1.93 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 86 | 3 | 3 | 2 | 1 | 3.47 | .278 | 1.11 | 7.4 | 2.7 | 3.9 | 23.1 | 19 | 9 | 9 | 0 | 7 | 10 | 2 | 0 | 0 | 1 | 2 | 1 | 1 | 3.17 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 3 | 3 | 0 | 0 | 6.75 | .362 | 1.70 | 10.9 | 5.1 | 4.5 | 14.2 | 17 | 11 | 11 | 4 | 8 | 7 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 7.43 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 70 | 3 | 3 | 0 | 2 | 6.16 | .337 | 1.53 | 8.1 | 5.7 | 7.6 | 19.0 | 17 | 13 | 13 | 2 | 12 | 16 | 0 | 0 | 0 | 0 | 1 | 0 | 2 | 4.58 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 66 | 3 | 3 | 0 | 1 | 4.95 | .368 | 1.75 | 11.3 | 4.5 | 5.0 | 20.0 | 25 | 11 | 11 | 3 | 10 | 11 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 5.35 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 7 | 0 | 1 | 0 | 1.46 | .196 | 0.73 | 6.8 | 0.0 | 9.8 | 12.1 | 9 | 2 | 2 | 2 | 0 | 13 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.00 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 8 | 0 | 0 | 1 | 4.50 | .375 | 1.80 | 13.5 | 2.7 | 8.1 | 10.0 | 15 | 5 | 5 | 1 | 3 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.40 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 68 | 6 | 0 | 0 | 2 | 9.53 | .485 | 2.65 | 18.0 | 9.0 | 7.2 | 5.2 | 10 | 6 | 6 | 2 | 5 | 4 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 10.20 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 7 | 0 | 0 | 1 | 3.86 | .300 | 1.14 | 5.1 | 5.1 | 6.4 | 7.0 | 4 | 3 | 3 | 1 | 4 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.57 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 64 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Perry, G.Perry, Gaylord >> | 34 | 1972 | R | 57 | 4 | 0 | 1 | 1 | 6.75 | .429 | 2.25 | 13.5 | 6.8 | 9.0 | 8.0 | 12 | 6 | 6 | 2 | 6 | 8 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 6.50 |