| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 16 | 16 | 5 | 8 | 3.92 | .311 | 1.34 | 8.2 | 3.8 | 8.0 | 103.1 | 94 | 46 | 45 | 13 | 44 | 91 | 1 | 0 | 0 | 0 | 9 | 2 | 0 | 4.21 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 15 | 15 | 7 | 5 | 4.60 | .333 | 1.47 | 9.5 | 3.7 | 3.8 | 94.0 | 99 | 54 | 48 | 5 | 39 | 40 | 1 | 0 | 0 | 0 | 9 | 3 | 1 | 4.18 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 14 | 14 | 3 | 10 | 5.62 | .344 | 1.52 | 8.8 | 5.0 | 6.1 | 83.1 | 81 | 57 | 52 | 13 | 46 | 56 | 0 | 0 | 0 | 0 | 5 | 4 | 0 | 5.49 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 42 | 0 | 3 | 4 | 2.11 | .247 | 0.98 | 6.5 | 2.4 | 8.6 | 64.0 | 46 | 18 | 15 | 2 | 17 | 61 | 0 | 2 | 2 | 0 | 0 | 0 | 2 | 2.30 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 43 | 0 | 2 | 5 | 6.08 | .314 | 1.37 | 8.8 | 3.6 | 7.6 | 50.1 | 49 | 36 | 34 | 8 | 20 | 42 | 0 | 6 | 2 | 0 | 0 | 0 | 2 | 4.60 |
| RP | McMahon, D.McMahon, Don >> | 37 | 1967 | R | 44 | 13 | 0 | 0 | 0 | 6.39 | .283 | 1.18 | 6.8 | 4.5 | 7.5 | 12.2 | 9 | 9 | 9 | 1 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.92 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 60 | 2 | 2 | 0 | 2 | 5.25 | .333 | 1.50 | 8.3 | 5.3 | 3.0 | 12.0 | 11 | 7 | 7 | 3 | 7 | 4 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 7.33 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 7 | 0 | 1 | 0 | 6.39 | .345 | 1.58 | 9.8 | 5.3 | 9.0 | 12.2 | 13 | 9 | 9 | 2 | 7 | 12 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.92 |