| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 32 | 32 | 16 | 7 | 3.83 | .311 | 1.32 | 8.2 | 3.7 | 7.3 | 185.2 | 169 | 79 | 79 | 23 | 77 | 151 | 0 | 0 | 0 | 0 | 19 | 5 | 5 | 4.31 |
| SP | Mathewson, C.Mathewson, Christy >> | 29 | 1909 | R | 85 | 32 | 32 | 10 | 14 | 3.85 | .260 | 1.03 | 6.9 | 2.4 | 4.7 | 213.0 | 163 | 94 | 91 | 20 | 56 | 112 | 5 | 0 | 0 | 1 | 18 | 6 | 4 | 4.04 |
| SP | Snell, B.Snell, Blake # $ >> | 25 | 2018 | L | 80 | 31 | 31 | 14 | 9 | 4.40 | .284 | 1.17 | 7.3 | 3.3 | 7.7 | 167.2 | 135 | 84 | 82 | 13 | 62 | 142 | 0 | 0 | 0 | 0 | 13 | 3 | 9 | 3.48 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 27 | 27 | 17 | 8 | 3.14 | .270 | 1.09 | 7.8 | 2.0 | 5.3 | 195.0 | 170 | 72 | 68 | 18 | 43 | 114 | 5 | 0 | 0 | 2 | 20 | 3 | 1 | 3.74 |
| SP | McDowell, S.McDowell, Sam # >> | 26 | 1968 | L | 45 | 29 | 29 | 11 | 10 | 4.29 | .288 | 1.19 | 7.5 | 3.2 | 7.3 | 184.2 | 154 | 93 | 88 | 19 | 66 | 149 | 3 | 0 | 0 | 0 | 14 | 4 | 2 | 3.86 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 81 | 0 | 3 | 2 | 3.66 | .303 | 1.29 | 6.8 | 4.8 | 9.1 | 103.1 | 78 | 42 | 42 | 8 | 55 | 104 | 0 | 12 | 3 | 0 | 0 | 2 | 1 | 3.65 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 76 | 0 | 4 | 4 | 2.62 | .231 | 0.88 | 6.7 | 1.3 | 7.5 | 99.2 | 74 | 30 | 29 | 10 | 14 | 82 | 0 | 18 | 3 | 0 | 0 | 2 | 0 | 3.14 |
| RP | Capps, C.Capps, Carter † >> | 24 | 2015 | R | 84 | 54 | 0 | 7 | 2 | 2.05 | .217 | 0.82 | 5.2 | 2.2 | 8.9 | 61.1 | 35 | 14 | 14 | 2 | 15 | 60 | 0 | 13 | 0 | 0 | 0 | 1 | 5 | 2.25 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 35 | 0 | 3 | 0 | 0.96 | .206 | 0.78 | 4.9 | 2.2 | 6.8 | 37.1 | 20 | 4 | 4 | 1 | 9 | 28 | 0 | 5 | 2 | 0 | 0 | 0 | 2 | 2.57 |