| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 18 | 18 | 8 | 5 | 3.12 | .263 | 1.06 | 7.9 | 1.6 | 3.9 | 132.2 | 116 | 52 | 46 | 13 | 24 | 57 | 1 | 0 | 0 | 0 | 13 | 2 | 2 | 4.01 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 17 | 3 | 5 | 3 | 5.58 | .328 | 1.45 | 10.8 | 2.3 | 3.2 | 71.0 | 85 | 45 | 44 | 14 | 18 | 25 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 5.66 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 15 | 15 | 5 | 3 | 5.85 | .362 | 1.65 | 11.4 | 3.5 | 7.3 | 72.1 | 91 | 48 | 47 | 8 | 28 | 58 | 0 | 0 | 0 | 0 | 6 | 4 | 4 | 4.17 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 29 | 0 | 3 | 1 | 3.06 | .284 | 1.19 | 7.5 | 3.3 | 10.3 | 35.1 | 29 | 17 | 12 | 3 | 13 | 40 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 2.94 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 22 | 0 | 1 | 3 | 2.49 | .343 | 1.57 | 9.0 | 5.6 | 7.7 | 21.2 | 21 | 7 | 6 | 2 | 13 | 18 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.38 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 7 | 0 | 0 | 0 | 2.16 | .167 | 0.60 | 5.6 | 0.0 | 7.9 | 8.1 | 5 | 2 | 2 | 2 | 0 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.50 |
| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 17 | 15 | 2 | 9 | 5.51 | .365 | 1.72 | 12.6 | 2.9 | 8.2 | 83.1 | 116 | 57 | 51 | 6 | 27 | 76 | 0 | 0 | 0 | 0 | 4 | 1 | 8 | 3.12 |