| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 34 | 34 | 15 | 10 | 3.99 | .292 | 1.22 | 8.3 | 2.7 | 5.2 | 239.0 | 221 | 110 | 106 | 19 | 71 | 139 | 2 | 0 | 0 | 1 | 19 | 3 | 5 | 3.80 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 31 | 31 | 10 | 14 | 5.04 | .326 | 1.44 | 9.2 | 3.8 | 5.2 | 194.2 | 199 | 119 | 109 | 24 | 81 | 113 | 2 | 0 | 0 | 0 | 15 | 2 | 6 | 4.73 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 94 | 0 | 10 | 3 | 2.64 | .247 | 0.98 | 5.5 | 3.3 | 6.1 | 109.0 | 67 | 36 | 32 | 9 | 40 | 74 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 3.82 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 67 | 0 | 4 | 2 | 2.42 | .273 | 1.10 | 6.1 | 3.9 | 9.3 | 81.2 | 55 | 22 | 22 | 8 | 35 | 84 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 3.58 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 62 | 0 | 1 | 4 | 3.10 | .273 | 1.13 | 6.4 | 3.9 | 8.4 | 72.2 | 51 | 25 | 25 | 8 | 31 | 67 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 3.88 |
| CL | Gagne, E.Gagne, Eric † >> | 27 | 2003 | R | 99 | 71 | 0 | 11 | 9 | 3.54 | .294 | 1.22 | 7.6 | 3.5 | 8.0 | 73.2 | 62 | 32 | 29 | 5 | 28 | 65 | 0 | 28 | 2 | 0 | 0 | 2 | 2 | 3.34 |
| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 9 | 0 | 0 | 1 | 4.50 | .368 | 1.67 | 10.5 | 4.5 | 3.0 | 12.0 | 14 | 6 | 6 | 1 | 6 | 4 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 5.17 |
| SU | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 68 | 0 | 1 | 4 | 4.97 | .338 | 1.50 | 8.4 | 5.3 | 8.4 | 70.2 | 65 | 40 | 39 | 8 | 41 | 65 | 0 | 5 | 8 | 0 | 0 | 2 | 1 | 4.47 |