| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 35 | 35 | 15 | 11 | 3.81 | .287 | 1.19 | 8.0 | 2.8 | 9.0 | 212.2 | 189 | 94 | 90 | 25 | 65 | 213 | 1 | 0 | 0 | 1 | 24 | 3 | 0 | 3.49 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 35 | 35 | 13 | 8 | 4.59 | .291 | 1.22 | 8.3 | 2.8 | 8.1 | 209.2 | 192 | 109 | 107 | 27 | 64 | 189 | 3 | 0 | 0 | 2 | 20 | 2 | 4 | 3.82 |
| SP | Alexander, P.Alexander, Pete # >> | 28 | 1915 | R | 88 | 35 | 34 | 10 | 10 | 4.50 | .316 | 1.38 | 9.9 | 2.6 | 4.2 | 208.0 | 229 | 112 | 104 | 17 | 59 | 98 | 4 | 0 | 0 | 1 | 18 | 0 | 2 | 3.97 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 86 | 0 | 4 | 8 | 4.28 | .336 | 1.49 | 10.7 | 2.8 | 9.8 | 94.2 | 112 | 49 | 45 | 10 | 29 | 102 | 0 | 32 | 5 | 0 | 0 | 3 | 1 | 3.23 |
| SU | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 94 | 97 | 0 | 10 | 2 | 5.86 | .344 | 1.55 | 10.4 | 3.7 | 6.7 | 110.2 | 127 | 77 | 72 | 19 | 45 | 82 | 0 | 3 | 4 | 0 | 0 | 2 | 1 | 5.04 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 80 | 69 | 0 | 4 | 1 | 3.16 | .306 | 1.30 | 8.6 | 3.2 | 7.9 | 85.1 | 81 | 32 | 30 | 8 | 30 | 75 | 0 | 0 | 0 | 0 | 0 | 2 | 5 | 3.59 |