| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 34 | 34 | 7 | 15 | 4.42 | .297 | 1.25 | 8.1 | 3.2 | 9.3 | 222.0 | 199 | 123 | 109 | 41 | 78 | 230 | 1 | 0 | 0 | 1 | 18 | 4 | 3 | 4.44 |
| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 98 | 33 | 33 | 15 | 10 | 3.79 | .292 | 1.21 | 9.0 | 1.9 | 9.9 | 239.2 | 240 | 106 | 101 | 29 | 51 | 263 | 5 | 0 | 0 | 2 | 19 | 5 | 5 | 3.08 |
| SP | Gallen, Z.Gallen, Zac # >> | 26 | 2022 | R | 92 | 32 | 32 | 9 | 15 | 4.65 | .308 | 1.30 | 8.5 | 3.2 | 8.4 | 195.2 | 184 | 103 | 101 | 31 | 70 | 183 | 1 | 0 | 0 | 0 | 16 | 7 | 9 | 4.37 |
| SP | Buehler, W.Buehler, Walker >> | 23 | 2018 | R | 84 | 32 | 32 | 8 | 15 | 5.79 | .348 | 1.57 | 10.2 | 4.0 | 9.4 | 174.0 | 197 | 115 | 112 | 39 | 77 | 182 | 0 | 0 | 0 | 0 | 10 | 4 | 6 | 5.22 |
| SP | Flaherty, J.Flaherty, Jack # >> | 23 | 2019 | R | 83 | 31 | 31 | 13 | 14 | 5.41 | .337 | 1.50 | 9.4 | 4.1 | 9.3 | 178.0 | 186 | 109 | 107 | 28 | 81 | 183 | 0 | 0 | 0 | 0 | 16 | 5 | 8 | 4.44 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 82 | 0 | 9 | 5 | 3.34 | .266 | 1.08 | 7.5 | 2.3 | 8.9 | 102.1 | 85 | 39 | 38 | 17 | 26 | 101 | 0 | 9 | 4 | 0 | 0 | 0 | 0 | 3.95 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 64 | 0 | 3 | 0 | 3.54 | .266 | 1.05 | 6.5 | 3.0 | 9.9 | 86.1 | 62 | 36 | 34 | 7 | 29 | 95 | 0 | 6 | 2 | 0 | 0 | 3 | 1 | 2.97 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 49 | 0 | 2 | 5 | 3.94 | .297 | 1.25 | 7.2 | 4.1 | 10.6 | 61.2 | 49 | 28 | 27 | 10 | 28 | 72 | 0 | 7 | 2 | 0 | 0 | 1 | 0 | 4.20 |
| RP | Jackson, M.Jackson, Mike >> | 30 | 1994 | R | 82 | 37 | 0 | 3 | 1 | 3.02 | .273 | 1.08 | 7.5 | 2.4 | 10.8 | 41.2 | 34 | 18 | 14 | 8 | 11 | 49 | 0 | 5 | 0 | 0 | 0 | 2 | 0 | 4.10 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 59 | 31 | 0 | 1 | 1 | 4.29 | .282 | 1.18 | 7.7 | 3.1 | 8.7 | 35.2 | 30 | 17 | 17 | 6 | 12 | 34 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.31 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 56 | 10 | 0 | 0 | 2 | 6.59 | .349 | 1.61 | 11.1 | 4.2 | 6.9 | 13.2 | 16 | 16 | 10 | 4 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.85 |