| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 36 | 36 | 20 | 10 | 3.27 | .274 | 1.12 | 7.1 | 3.0 | 10.5 | 223.0 | 175 | 84 | 81 | 31 | 75 | 259 | 1 | 0 | 0 | 0 | 24 | 2 | 0 | 3.52 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 95 | 35 | 35 | 14 | 13 | 3.82 | .298 | 1.26 | 8.0 | 3.3 | 8.4 | 214.1 | 191 | 99 | 91 | 29 | 79 | 199 | 4 | 0 | 0 | 0 | 19 | 3 | 6 | 4.05 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 87 | 33 | 33 | 14 | 8 | 3.57 | .281 | 1.15 | 7.6 | 2.8 | 6.0 | 174.0 | 146 | 71 | 69 | 29 | 54 | 116 | 0 | 0 | 0 | 0 | 10 | 4 | 8 | 4.83 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 81 | 33 | 33 | 16 | 7 | 3.95 | .305 | 1.28 | 8.7 | 2.8 | 7.0 | 212.0 | 204 | 95 | 93 | 21 | 67 | 166 | 1 | 0 | 0 | 0 | 17 | 8 | 7 | 3.78 |
| SP | Higuera, T.Higuera, Teddy >> | 30 | 1988 | L | 64 | 30 | 30 | 10 | 10 | 4.66 | .327 | 1.43 | 8.8 | 4.0 | 6.4 | 174.0 | 171 | 93 | 90 | 32 | 78 | 123 | 0 | 0 | 0 | 0 | 17 | 5 | 0 | 5.41 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 94 | 83 | 0 | 4 | 4 | 2.56 | .229 | 0.86 | 5.1 | 2.7 | 10.8 | 81.0 | 46 | 24 | 23 | 15 | 24 | 97 | 0 | 43 | 1 | 0 | 0 | 2 | 3 | 3.98 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 65 | 82 | 0 | 4 | 4 | 3.48 | .292 | 1.23 | 8.2 | 2.8 | 10.3 | 93.0 | 85 | 36 | 36 | 10 | 29 | 106 | 0 | 2 | 4 | 0 | 0 | 1 | 3 | 3.09 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 54 | 95 | 0 | 7 | 1 | 3.44 | .279 | 1.15 | 6.8 | 3.6 | 5.8 | 73.1 | 55 | 30 | 28 | 13 | 29 | 47 | 0 | 1 | 3 | 0 | 0 | 1 | 1 | 5.26 |
| RP | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 92 | 76 | 0 | 2 | 5 | 4.11 | .315 | 1.37 | 7.9 | 4.5 | 9.0 | 72.1 | 63 | 34 | 33 | 10 | 36 | 72 | 0 | 6 | 2 | 0 | 0 | 1 | 1 | 4.35 |
| SP | Vazquez, J.Vazquez, Javier >> | 33 | 2009 | R | 48 | 32 | 1 | 6 | 4 | 4.60 | .289 | 1.22 | 8.4 | 2.7 | 7.5 | 105.2 | 98 | 57 | 54 | 23 | 31 | 88 | 0 | 1 | 0 | 0 | 1 | 0 | 5 | 5.06 |