| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 26 | 26 | 6 | 6 | 4.51 | .330 | 1.44 | 9.8 | 3.2 | 9.4 | 151.2 | 165 | 89 | 76 | 17 | 53 | 158 | 0 | 0 | 0 | 0 | 11 | 6 | 4 | 3.54 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 25 | 25 | 6 | 12 | 5.95 | .335 | 1.49 | 9.7 | 3.7 | 7.0 | 137.2 | 148 | 97 | 91 | 15 | 57 | 106 | 1 | 0 | 0 | 0 | 6 | 3 | 0 | 4.19 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 25 | 25 | 12 | 10 | 3.35 | .303 | 1.29 | 8.9 | 2.8 | 7.4 | 150.1 | 148 | 68 | 56 | 15 | 46 | 123 | 0 | 0 | 0 | 0 | 18 | 2 | 2 | 3.62 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 27 | 24 | 3 | 12 | 5.29 | .342 | 1.52 | 10.3 | 3.5 | 2.8 | 129.1 | 147 | 82 | 76 | 21 | 50 | 40 | 0 | 1 | 0 | 0 | 11 | 5 | 4 | 5.78 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 84 | 0 | 5 | 4 | 3.77 | .311 | 1.31 | 7.2 | 4.7 | 9.1 | 102.2 | 82 | 49 | 43 | 12 | 53 | 103 | 0 | 6 | 6 | 0 | 0 | 4 | 5 | 4.19 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 72 | 0 | 4 | 7 | 4.75 | .295 | 1.26 | 8.7 | 2.7 | 7.9 | 94.2 | 91 | 50 | 50 | 7 | 28 | 83 | 0 | 5 | 4 | 0 | 0 | 0 | 3 | 3.10 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 69 | 0 | 3 | 9 | 5.26 | .317 | 1.39 | 8.1 | 4.4 | 9.0 | 89.0 | 80 | 56 | 52 | 17 | 44 | 89 | 0 | 5 | 4 | 0 | 0 | 0 | 1 | 4.97 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 64 | 0 | 3 | 3 | 4.35 | .328 | 1.42 | 8.5 | 4.4 | 6.8 | 68.1 | 64 | 36 | 33 | 11 | 33 | 51 | 0 | 2 | 1 | 0 | 0 | 3 | 2 | 5.19 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 48 | 0 | 1 | 6 | 4.19 | .302 | 1.28 | 8.6 | 3.0 | 8.6 | 62.1 | 59 | 33 | 29 | 9 | 21 | 59 | 0 | 2 | 3 | 0 | 0 | 1 | 5 | 4.05 |