| SP | deGrom, J.deGrom, Jacob † >> | 33 | 2021 | R | 100 | 20 | 20 | 12 | 4 | 3.38 | .273 | 1.11 | 7.5 | 2.5 | 9.4 | 138.1 | 115 | 52 | 52 | 20 | 39 | 144 | 2 | 0 | 0 | 0 | 12 | 2 | 0 | 3.69 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 86 | 20 | 20 | 14 | 5 | 3.60 | .287 | 1.19 | 8.9 | 1.9 | 6.1 | 165.0 | 163 | 73 | 66 | 13 | 34 | 112 | 12 | 0 | 0 | 1 | 12 | 2 | 3 | 3.32 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 77 | 19 | 19 | 9 | 6 | 6.47 | .358 | 1.65 | 11.7 | 3.2 | 8.3 | 119.2 | 155 | 88 | 86 | 19 | 42 | 110 | 0 | 0 | 0 | 0 | 5 | 3 | 1 | 4.36 |
| SP | Darvish, Y.Darvish, Yu >> | 26 | 2013 | R | 55 | 19 | 19 | 7 | 7 | 4.38 | .340 | 1.52 | 7.9 | 5.8 | 9.3 | 113.0 | 99 | 61 | 55 | 15 | 73 | 117 | 0 | 0 | 0 | 0 | 8 | 3 | 3 | 4.67 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 50 | 0 | 4 | 2 | 2.95 | .263 | 1.03 | 6.7 | 2.6 | 9.8 | 79.1 | 59 | 31 | 26 | 10 | 23 | 86 | 0 | 6 | 4 | 0 | 0 | 3 | 0 | 3.46 |
| RP | Chapman, A.Chapman, Aroldis >> | 24 | 2012 | L | 88 | 39 | 0 | 0 | 1 | 3.04 | .279 | 1.16 | 5.2 | 5.4 | 11.1 | 47.1 | 27 | 19 | 16 | 4 | 28 | 58 | 0 | 8 | 0 | 0 | 0 | 0 | 1 | 3.43 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 93 | 25 | 0 | 2 | 2 | 5.12 | .269 | 1.11 | 7.8 | 2.3 | 10.2 | 31.2 | 27 | 18 | 18 | 7 | 8 | 35 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 4.45 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 75 | 10 | 0 | 0 | 3 | 18.00 | .500 | 2.88 | 20.3 | 5.6 | 6.8 | 8.0 | 18 | 16 | 16 | 7 | 5 | 6 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 15.13 |
| RP | Nelson, J.Nelson, Jeff >> | 29 | 1995 | R | 14 | 21 | 0 | 2 | 0 | 2.36 | .263 | 1.07 | 7.1 | 2.6 | 10.9 | 42.0 | 33 | 12 | 11 | 5 | 12 | 51 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.98 |