| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 97 | 19 | 19 | 10 | 3 | 3.33 | .291 | 1.21 | 6.8 | 4.1 | 9.5 | 124.1 | 94 | 48 | 46 | 14 | 56 | 131 | 0 | 0 | 0 | 0 | 12 | 3 | 6 | 3.78 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 18 | 18 | 7 | 10 | 5.33 | .315 | 1.35 | 8.6 | 3.7 | 8.8 | 101.1 | 96 | 60 | 60 | 18 | 41 | 99 | 0 | 0 | 0 | 0 | 8 | 3 | 0 | 4.66 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 84 | 18 | 18 | 4 | 11 | 6.47 | .366 | 1.68 | 10.4 | 4.8 | 6.8 | 104.1 | 120 | 77 | 75 | 17 | 55 | 79 | 2 | 0 | 0 | 0 | 5 | 6 | 1 | 5.37 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 17 | 17 | 7 | 5 | 5.23 | .311 | 1.34 | 8.9 | 3.1 | 8.7 | 103.1 | 102 | 61 | 60 | 14 | 36 | 100 | 2 | 0 | 0 | 1 | 9 | 2 | 1 | 3.93 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 70 | 17 | 17 | 6 | 5 | 6.29 | .341 | 1.55 | 10.7 | 3.3 | 6.7 | 103.0 | 122 | 72 | 72 | 16 | 38 | 77 | 1 | 0 | 0 | 0 | 5 | 0 | 2 | 4.63 |
| CL | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 40 | 0 | 3 | 3 | 2.12 | .231 | 0.88 | 5.3 | 2.7 | 11.0 | 46.2 | 27 | 11 | 11 | 2 | 14 | 56 | 0 | 21 | 1 | 0 | 0 | 1 | 1 | 2.11 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 44 | 0 | 5 | 0 | 3.95 | .317 | 1.39 | 8.3 | 4.3 | 9.7 | 54.2 | 50 | 25 | 24 | 5 | 26 | 58 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.50 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 78 | 37 | 0 | 1 | 1 | 2.39 | .315 | 1.33 | 7.3 | 4.9 | 8.8 | 37.2 | 30 | 10 | 10 | 3 | 20 | 36 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 3.89 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 72 | 24 | 0 | 3 | 1 | 3.64 | .252 | 0.94 | 6.8 | 1.9 | 13.3 | 29.2 | 22 | 12 | 12 | 5 | 6 | 43 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 3.10 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 69 | 27 | 0 | 0 | 1 | 4.12 | .306 | 1.32 | 8.3 | 3.7 | 8.8 | 39.1 | 36 | 19 | 18 | 3 | 16 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.28 |