| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 89 | 10 | 10 | 2 | 3 | 5.40 | .315 | 1.36 | 9.8 | 2.5 | 10.3 | 55.0 | 60 | 33 | 33 | 10 | 15 | 63 | 0 | 0 | 0 | 0 | 6 | 1 | 0 | 3.95 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 53 | 9 | 9 | 2 | 4 | 4.93 | .336 | 1.46 | 7.7 | 5.5 | 10.1 | 49.1 | 42 | 27 | 27 | 9 | 30 | 55 | 0 | 0 | 0 | 0 | 5 | 3 | 1 | 5.16 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 91 | 23 | 0 | 1 | 2 | 4.20 | .318 | 1.40 | 8.1 | 4.5 | 8.1 | 30.0 | 27 | 16 | 14 | 2 | 15 | 27 | 0 | 0 | 4 | 0 | 0 | 0 | 0 | 3.57 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 93 | 26 | 0 | 4 | 3 | 1.88 | .218 | 0.80 | 5.5 | 1.9 | 10.0 | 28.2 | 17 | 11 | 6 | 4 | 6 | 31 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 3.39 |
| RP | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 80 | 22 | 0 | 3 | 1 | 2.86 | .320 | 1.36 | 7.4 | 4.9 | 7.0 | 22.0 | 18 | 7 | 7 | 2 | 12 | 17 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.41 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 75 | 22 | 0 | 2 | 0 | 2.01 | .247 | 0.99 | 6.1 | 2.9 | 9.4 | 22.1 | 15 | 5 | 5 | 0 | 7 | 23 | 0 | 2 | 0 | 0 | 0 | 0 | 3 | 1.86 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 67 | 14 | 0 | 1 | 0 | 1.08 | .206 | 0.78 | 5.1 | 2.3 | 11.8 | 16.2 | 9 | 2 | 2 | 0 | 4 | 21 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1.13 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 77 | 10 | 0 | 0 | 1 | 3.29 | .196 | 0.73 | 5.5 | 1.4 | 6.2 | 13.2 | 8 | 5 | 5 | 1 | 2 | 9 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.08 |