| SP | Kershaw, C.Kershaw, Clayton # >> | 28 | 2016 | L | 99 | 19 | 19 | 8 | 7 | 4.62 | .300 | 1.27 | 9.6 | 1.8 | 7.6 | 113.0 | 121 | 63 | 58 | 18 | 22 | 96 | 2 | 0 | 0 | 0 | 10 | 2 | 1 | 4.01 |
| SP | Reulbach, E.Reulbach, Ed $$ >> | 24 | 1906 | R | 60 | 18 | 18 | 7 | 5 | 4.56 | .357 | 1.61 | 9.5 | 5.0 | 4.8 | 102.2 | 108 | 54 | 52 | 4 | 57 | 54 | 1 | 0 | 0 | 0 | 7 | 6 | 0 | 4.30 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 17 | 17 | 7 | 6 | 5.30 | .354 | 1.64 | 10.5 | 4.4 | 7.7 | 91.2 | 106 | 57 | 54 | 14 | 44 | 78 | 0 | 0 | 0 | 0 | 9 | 1 | 1 | 4.77 |
| CL | Doolittle, S.Doolittle, Sean $ >> | 31 | 2018 | L | 98 | 35 | 0 | 1 | 2 | 4.38 | .291 | 1.23 | 7.8 | 3.2 | 7.2 | 39.0 | 34 | 19 | 19 | 4 | 14 | 31 | 0 | 20 | 3 | 0 | 0 | 0 | 0 | 3.82 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 46 | 0 | 1 | 0 | 3.56 | .238 | 0.92 | 5.1 | 3.3 | 8.9 | 60.2 | 34 | 24 | 24 | 8 | 22 | 59 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.92 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 38 | 0 | 4 | 1 | 3.43 | .320 | 1.39 | 9.6 | 3.1 | 4.7 | 44.2 | 47 | 18 | 17 | 4 | 15 | 23 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.23 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 32 | 0 | 2 | 1 | 2.56 | .247 | 0.96 | 5.0 | 3.8 | 7.1 | 38.2 | 21 | 14 | 11 | 4 | 16 | 30 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 4.13 |
| SU | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 31 | 0 | 0 | 4 | 3.07 | .293 | 1.22 | 6.1 | 4.8 | 8.3 | 41.0 | 28 | 14 | 14 | 4 | 22 | 38 | 0 | 1 | 2 | 0 | 0 | 1 | 1 | 4.10 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 70 | 29 | 0 | 3 | 1 | 3.26 | .283 | 1.15 | 5.1 | 5.4 | 7.5 | 30.1 | 17 | 11 | 11 | 2 | 18 | 25 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 4.10 |
| RP | Williamson, S.Williamson, Scott >> | 23 | 1999 | R | 45 | 20 | 0 | 1 | 0 | 1.25 | .330 | 1.48 | 7.7 | 6.0 | 6.9 | 21.2 | 18 | 4 | 3 | 2 | 14 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 4.71 |