| SP | deGrom, J.deGrom, Jacob † $ >> | 33 | 2021 | R | 100 | 29 | 29 | 13 | 7 | 3.16 | .272 | 1.10 | 7.4 | 2.5 | 8.6 | 191.0 | 158 | 72 | 67 | 21 | 52 | 182 | 0 | 0 | 0 | 0 | 20 | 4 | 0 | 3.40 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 28 | 28 | 9 | 17 | 5.51 | .323 | 1.40 | 9.7 | 2.9 | 7.9 | 170.0 | 184 | 112 | 104 | 29 | 54 | 150 | 3 | 0 | 0 | 0 | 13 | 5 | 4 | 4.49 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 27 | 27 | 8 | 5 | 4.29 | .314 | 1.32 | 8.9 | 3.0 | 5.2 | 147.0 | 145 | 72 | 70 | 16 | 49 | 85 | 0 | 0 | 0 | 0 | 10 | 8 | 1 | 4.42 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 27 | 27 | 12 | 9 | 4.26 | .314 | 1.35 | 9.8 | 2.3 | 5.2 | 194.1 | 212 | 100 | 92 | 23 | 50 | 113 | 6 | 0 | 0 | 1 | 14 | 5 | 1 | 4.23 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 57 | 0 | 7 | 8 | 4.37 | .282 | 1.18 | 8.5 | 2.2 | 8.4 | 57.2 | 54 | 29 | 28 | 8 | 14 | 53 | 0 | 26 | 9 | 0 | 0 | 0 | 1 | 3.70 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 70 | 0 | 6 | 4 | 3.55 | .286 | 1.19 | 7.6 | 3.2 | 7.8 | 91.1 | 77 | 36 | 36 | 13 | 32 | 79 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 4.21 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 48 | 0 | 5 | 1 | 4.36 | .300 | 1.29 | 8.2 | 3.6 | 7.8 | 53.2 | 48 | 26 | 26 | 9 | 21 | 46 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.66 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 37 | 0 | 0 | 3 | 4.62 | .331 | 1.46 | 8.0 | 5.1 | 10.7 | 37.0 | 33 | 20 | 19 | 6 | 21 | 44 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.51 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 6 | 0 | 2 | 0 | 0.00 | .171 | 0.62 | 6.0 | 0.0 | 12.0 | 9.2 | 6 | 0 | 0 | 0 | 0 | 12 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0.33 |