| SP | Kershaw, C.Kershaw, Clayton $ >> | 28 | 2016 | L | 99 | 29 | 29 | 11 | 11 | 3.68 | .285 | 1.17 | 8.7 | 1.9 | 7.1 | 198.1 | 192 | 83 | 81 | 22 | 41 | 157 | 5 | 0 | 0 | 2 | 18 | 4 | 4 | 3.54 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 28 | 28 | 9 | 7 | 4.36 | .293 | 1.22 | 8.4 | 2.6 | 6.8 | 177.2 | 166 | 90 | 86 | 18 | 51 | 133 | 2 | 0 | 0 | 1 | 13 | 4 | 4 | 3.75 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 27 | 27 | 8 | 10 | 4.86 | .323 | 1.40 | 8.6 | 4.1 | 4.0 | 163.0 | 155 | 97 | 88 | 14 | 74 | 73 | 1 | 0 | 0 | 0 | 12 | 4 | 3 | 4.66 |
| SP | Sutton, D.Sutton, Don # >> | 27 | 1972 | R | 82 | 26 | 26 | 11 | 9 | 3.82 | .296 | 1.25 | 8.2 | 3.1 | 5.2 | 172.0 | 156 | 83 | 73 | 12 | 59 | 99 | 6 | 0 | 0 | 2 | 15 | 2 | 9 | 3.82 |
| CL | Wagner, B.Wagner, Billy † >> | 28 | 1999 | L | 95 | 65 | 0 | 6 | 5 | 3.17 | .263 | 1.07 | 6.5 | 3.2 | 10.3 | 71.0 | 51 | 25 | 25 | 8 | 25 | 81 | 0 | 37 | 6 | 0 | 0 | 0 | 1 | 3.24 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 70 | 0 | 6 | 2 | 2.90 | .278 | 1.16 | 7.4 | 3.0 | 9.4 | 90.0 | 74 | 34 | 29 | 12 | 30 | 94 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 3.64 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 58 | 0 | 7 | 1 | 3.36 | .310 | 1.33 | 7.3 | 4.8 | 8.3 | 69.2 | 56 | 30 | 26 | 4 | 37 | 64 | 0 | 1 | 6 | 0 | 0 | 1 | 1 | 3.55 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 47 | 0 | 4 | 2 | 3.10 | .275 | 1.14 | 7.1 | 3.1 | 7.3 | 58.0 | 46 | 21 | 20 | 6 | 20 | 47 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 3.76 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 41 | 0 | 4 | 2 | 2.15 | .250 | 0.96 | 3.7 | 4.9 | 9.2 | 46.0 | 19 | 11 | 11 | 4 | 25 | 47 | 0 | 2 | 0 | 0 | 0 | 2 | 3 | 3.85 |