| SP | Ryan, N.Ryan, Nolan † $$ >> | 44 | 1991 | R | 73 | 34 | 34 | 18 | 9 | 3.26 | .266 | 1.08 | 6.4 | 3.3 | 8.5 | 223.1 | 158 | 86 | 81 | 22 | 83 | 210 | 1 | 0 | 0 | 1 | 25 | 2 | 11 | 3.54 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 33 | 33 | 15 | 14 | 3.77 | .275 | 1.11 | 7.9 | 2.2 | 7.8 | 229.1 | 200 | 101 | 96 | 27 | 55 | 199 | 6 | 0 | 0 | 2 | 20 | 6 | 3 | 3.59 |
| SP | Brown, M.Brown, Mordecai # >> | 32 | 1908 | R | 85 | 33 | 33 | 16 | 10 | 3.37 | .277 | 1.11 | 7.9 | 2.1 | 4.1 | 253.2 | 221 | 99 | 95 | 26 | 60 | 116 | 7 | 0 | 0 | 1 | 19 | 10 | 6 | 4.25 |
| SP | Gibson, B.Gibson, Bob † >> | 33 | 1968 | R | 92 | 34 | 34 | 18 | 9 | 3.69 | .297 | 1.25 | 8.6 | 2.7 | 5.7 | 244.0 | 233 | 104 | 100 | 26 | 72 | 154 | 7 | 0 | 0 | 2 | 20 | 4 | 2 | 4.06 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 70 | 0 | 5 | 8 | 2.95 | .264 | 1.03 | 7.8 | 1.5 | 9.1 | 85.1 | 74 | 30 | 28 | 9 | 14 | 86 | 0 | 1 | 3 | 0 | 0 | 4 | 0 | 2.99 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 37 | 0 | 0 | 2 | 3.48 | .263 | 1.07 | 7.0 | 2.7 | 8.8 | 44.0 | 34 | 17 | 17 | 6 | 13 | 43 | 0 | 1 | 1 | 0 | 0 | 0 | 4 | 3.70 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 23 | 0 | 3 | 1 | 2.05 | .262 | 1.03 | 5.5 | 3.8 | 9.0 | 26.1 | 16 | 6 | 6 | 1 | 11 | 26 | 0 | 0 | 1 | 0 | 0 | 1 | 4 | 2.88 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 14 | 0 | 3 | 1 | 1.96 | .281 | 1.17 | 6.3 | 4.3 | 5.1 | 23.0 | 16 | 7 | 5 | 2 | 11 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.43 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 23 | 0 | 4 | 0 | 4.01 | .288 | 1.22 | 6.0 | 5.3 | 7.9 | 24.2 | 16 | 12 | 11 | 3 | 14 | 21 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.63 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 31 | 31 | 13 | 10 | 3.65 | .293 | 1.23 | 7.2 | 3.9 | 7.6 | 212.1 | 170 | 91 | 86 | 16 | 92 | 180 | 4 | 0 | 0 | 1 | 18 | 2 | 3 | 3.61 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 67 | 19 | 0 | 6 | 1 | 3.99 | .298 | 1.25 | 8.9 | 2.4 | 5.3 | 88.0 | 87 | 42 | 39 | 11 | 23 | 52 | 0 | 0 | 0 | 0 | 0 | 2 | 5 | 4.30 |
| CL | Chapman, A.Chapman, Aroldis † $ >> | 26 | 2014 | L | 93 | 62 | 0 | 0 | 1 | 2.38 | .283 | 1.18 | 6.1 | 4.7 | 9.3 | 56.2 | 38 | 15 | 15 | 2 | 29 | 58 | 0 | 53 | 3 | 0 | 0 | 0 | 1 | 2.95 |