| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 74 | 31 | 27 | 9 | 10 | 4.23 | .290 | 1.22 | 7.8 | 3.3 | 5.4 | 210.2 | 181 | 111 | 99 | 27 | 77 | 125 | 3 | 0 | 0 | 0 | 12 | 0 | 8 | 4.58 |
| SP | Scherzer, M.Scherzer, Max # >> | 33 | 2017 | R | 95 | 33 | 33 | 11 | 12 | 4.83 | .304 | 1.29 | 8.5 | 3.2 | 8.6 | 199.1 | 187 | 112 | 107 | 30 | 70 | 191 | 1 | 0 | 0 | 0 | 16 | 4 | 1 | 4.16 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 33 | 33 | 10 | 16 | 4.26 | .298 | 1.27 | 9.0 | 2.4 | 5.6 | 239.0 | 240 | 127 | 113 | 32 | 63 | 150 | 5 | 0 | 0 | 1 | 17 | 2 | 2 | 4.30 |
| RP | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 88 | 58 | 0 | 4 | 10 | 4.27 | .311 | 1.31 | 9.2 | 2.6 | 9.3 | 59.0 | 60 | 29 | 28 | 5 | 17 | 61 | 0 | 34 | 4 | 0 | 0 | 3 | 0 | 3.05 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 30 | 0 | 3 | 1 | 2.48 | .287 | 1.21 | 3.7 | 7.1 | 9.0 | 29.0 | 12 | 10 | 8 | 2 | 23 | 29 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.28 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 81 | 43 | 0 | 6 | 1 | 2.64 | .239 | 0.92 | 5.9 | 2.5 | 9.8 | 47.2 | 31 | 17 | 14 | 6 | 13 | 51 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 3.38 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 49 | 0 | 3 | 2 | 3.00 | .289 | 1.22 | 7.1 | 3.9 | 6.6 | 60.0 | 47 | 21 | 20 | 6 | 26 | 44 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.13 |
| RP | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 93 | 51 | 0 | 4 | 2 | 3.90 | .357 | 1.63 | 9.5 | 5.3 | 7.8 | 60.0 | 63 | 27 | 26 | 7 | 35 | 52 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 4.63 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 19 | 0 | 0 | 2 | 7.36 | .375 | 1.80 | 14.5 | 2.0 | 10.0 | 18.1 | 29 | 16 | 15 | 2 | 4 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.89 |
| SP | Schmidt, J.Schmidt, Jason # >> | 30 | 2003 | R | 68 | 15 | 12 | 6 | 4 | 5.74 | .328 | 1.47 | 10.2 | 3.1 | 8.0 | 73.2 | 83 | 52 | 47 | 17 | 25 | 65 | 0 | 0 | 0 | 0 | 4 | 0 | 1 | 5.27 |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 14 | 8 | 3 | 5 | 4.78 | .335 | 1.49 | 10.5 | 3.0 | 7.6 | 84.2 | 98 | 51 | 45 | 16 | 28 | 71 | 1 | 0 | 0 | 0 | 3 | 2 | 2 | 4.86 |
| CL | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 53 | 0 | 3 | 2 | 3.11 | .315 | 1.35 | 7.7 | 4.4 | 9.3 | 55.0 | 47 | 23 | 19 | 7 | 27 | 57 | 0 | 7 | 2 | 0 | 0 | 2 | 0 | 4.16 |