| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 36 | 36 | 16 | 13 | 4.06 | .288 | 1.18 | 7.9 | 2.7 | 8.8 | 217.1 | 191 | 98 | 98 | 23 | 65 | 211 | 1 | 0 | 0 | 1 | 20 | 8 | 0 | 3.44 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 34 | 34 | 12 | 11 | 4.78 | .313 | 1.36 | 8.8 | 3.4 | 8.5 | 205.1 | 201 | 114 | 109 | 30 | 78 | 194 | 2 | 0 | 0 | 1 | 14 | 1 | 6 | 4.17 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 33 | 33 | 16 | 5 | 3.63 | .296 | 1.23 | 8.2 | 2.9 | 4.6 | 230.2 | 210 | 100 | 93 | 26 | 73 | 118 | 8 | 0 | 0 | 3 | 21 | 8 | 4 | 4.50 |
| SP | Fernandez, S.Fernandez, Sid # >> | 23 | 1985 | L | 49 | 33 | 33 | 16 | 11 | 3.33 | .280 | 1.14 | 6.4 | 3.8 | 7.5 | 213.2 | 152 | 81 | 79 | 17 | 91 | 178 | 1 | 0 | 0 | 1 | 22 | 6 | 3 | 3.73 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 92 | 0 | 5 | 4 | 4.99 | .308 | 1.32 | 7.9 | 4.0 | 10.1 | 110.0 | 96 | 64 | 61 | 19 | 49 | 123 | 0 | 2 | 2 | 0 | 0 | 2 | 7 | 4.40 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 63 | 0 | 1 | 6 | 4.68 | .348 | 1.60 | 8.9 | 5.6 | 7.5 | 67.1 | 66 | 36 | 35 | 10 | 42 | 56 | 0 | 3 | 5 | 0 | 0 | 0 | 1 | 5.15 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 49 | 0 | 7 | 2 | 2.86 | .277 | 1.13 | 6.4 | 3.9 | 8.8 | 56.2 | 40 | 18 | 18 | 3 | 24 | 55 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.07 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 37 | 0 | 2 | 0 | 3.92 | .271 | 1.11 | 8.3 | 1.8 | 9.0 | 41.1 | 38 | 18 | 18 | 6 | 8 | 41 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.49 |
| CL | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 73 | 0 | 3 | 9 | 4.42 | .323 | 1.42 | 8.8 | 4.1 | 8.4 | 75.1 | 73 | 43 | 37 | 7 | 34 | 70 | 0 | 36 | 6 | 0 | 0 | 1 | 2 | 3.75 |