| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 34 | 34 | 20 | 7 | 3.38 | .267 | 1.08 | 7.7 | 2.0 | 4.9 | 236.2 | 203 | 100 | 89 | 20 | 52 | 128 | 6 | 0 | 0 | 3 | 20 | 3 | 1 | 3.72 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 34 | 34 | 15 | 4 | 2.72 | .281 | 1.16 | 7.5 | 2.9 | 5.0 | 235.1 | 195 | 82 | 71 | 17 | 77 | 131 | 0 | 0 | 0 | 0 | 26 | 4 | 4 | 3.86 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 21 | 21 | 7 | 8 | 5.76 | .342 | 1.55 | 8.8 | 5.1 | 7.6 | 111.0 | 109 | 75 | 71 | 11 | 63 | 94 | 0 | 0 | 0 | 0 | 7 | 1 | 1 | 4.32 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 30 | 30 | 12 | 13 | 4.77 | .314 | 1.36 | 9.3 | 2.9 | 5.1 | 200.0 | 207 | 112 | 106 | 30 | 65 | 113 | 4 | 0 | 0 | 0 | 13 | 2 | 1 | 4.83 |
| CL | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 94 | 68 | 0 | 2 | 7 | 3.24 | .290 | 1.21 | 5.2 | 5.8 | 10.0 | 75.0 | 43 | 27 | 27 | 9 | 48 | 83 | 0 | 44 | 4 | 0 | 0 | 1 | 0 | 4.31 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 68 | 0 | 2 | 1 | 3.22 | .278 | 1.14 | 7.3 | 3.1 | 9.0 | 72.2 | 58 | 27 | 26 | 7 | 25 | 72 | 0 | 8 | 6 | 0 | 0 | 1 | 0 | 3.35 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 83 | 0 | 5 | 0 | 3.30 | .254 | 1.02 | 6.0 | 3.3 | 10.2 | 62.2 | 41 | 24 | 23 | 10 | 23 | 70 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 3.95 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 59 | 0 | 6 | 2 | 3.64 | .267 | 1.10 | 5.8 | 4.1 | 7.0 | 59.1 | 38 | 30 | 24 | 6 | 27 | 46 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 4.14 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 71 | 0 | 3 | 2 | 4.70 | .282 | 1.16 | 7.8 | 2.7 | 9.2 | 59.1 | 51 | 32 | 31 | 13 | 18 | 60 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.80 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 14 | 3 | 2 | 2 | 4.77 | .347 | 1.59 | 10.5 | 3.8 | 5.9 | 66.0 | 77 | 36 | 35 | 9 | 28 | 43 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.74 |