| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 16 | 16 | 7 | 5 | 3.93 | .299 | 1.26 | 8.3 | 3.1 | 8.0 | 112.1 | 103 | 50 | 49 | 11 | 39 | 99 | 6 | 0 | 0 | 1 | 11 | 2 | 1 | 3.61 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 16 | 16 | 8 | 6 | 5.60 | .329 | 1.46 | 10.0 | 3.1 | 8.6 | 106.0 | 118 | 69 | 66 | 15 | 37 | 101 | 2 | 0 | 0 | 0 | 6 | 1 | 4 | 4.01 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 16 | 16 | 5 | 9 | 5.35 | .344 | 1.55 | 10.1 | 3.9 | 4.6 | 112.2 | 126 | 68 | 67 | 14 | 49 | 57 | 1 | 0 | 0 | 1 | 7 | 2 | 1 | 4.97 |
| SP | Pfiester, J.Pfiester, Jack # >> | 28 | 1906 | L | 74 | 15 | 15 | 9 | 5 | 3.14 | .263 | 1.07 | 7.1 | 2.6 | 4.5 | 123.1 | 97 | 51 | 43 | 12 | 35 | 62 | 10 | 0 | 0 | 0 | 11 | 0 | 2 | 4.11 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 39 | 0 | 2 | 1 | 2.93 | .270 | 1.11 | 7.8 | 2.2 | 7.2 | 46.0 | 40 | 15 | 15 | 7 | 11 | 37 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 4.09 |
| RP | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 31 | 0 | 2 | 1 | 2.61 | .266 | 1.04 | 5.7 | 3.7 | 8.1 | 41.1 | 26 | 12 | 12 | 3 | 17 | 37 | 0 | 5 | 0 | 0 | 0 | 2 | 0 | 3.54 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 21 | 0 | 1 | 1 | 3.54 | .317 | 1.39 | 7.4 | 5.1 | 7.4 | 28.0 | 23 | 12 | 11 | 4 | 16 | 23 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.93 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 17 | 0 | 1 | 2 | 4.62 | .350 | 1.58 | 9.7 | 4.7 | 6.8 | 25.1 | 27 | 13 | 13 | 3 | 13 | 19 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 4.72 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 62 | 15 | 0 | 1 | 1 | 4.24 | .329 | 1.47 | 8.5 | 4.8 | 6.4 | 17.0 | 16 | 9 | 8 | 2 | 9 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.71 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 9 | 1 | 2 | 1 | 4.73 | .333 | 1.50 | 7.6 | 6.2 | 3.5 | 13.1 | 11 | 8 | 7 | 3 | 9 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 7.31 |