| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 34 | 34 | 11 | 16 | 5.30 | .317 | 1.37 | 8.9 | 3.5 | 8.6 | 225.2 | 223 | 136 | 133 | 35 | 87 | 216 | 2 | 0 | 0 | 1 | 14 | 4 | 4 | 4.32 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 12 | 14 | 4.94 | .321 | 1.41 | 9.1 | 3.6 | 8.1 | 224.0 | 226 | 131 | 123 | 30 | 89 | 202 | 3 | 0 | 0 | 1 | 14 | 2 | 4 | 4.16 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 73 | 32 | 32 | 11 | 13 | 5.48 | .350 | 1.60 | 10.8 | 3.7 | 4.5 | 216.2 | 258 | 149 | 132 | 25 | 89 | 108 | 2 | 0 | 0 | 0 | 13 | 3 | 3 | 4.78 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 86 | 0 | 0 | 5 | 2.62 | .271 | 1.11 | 6.6 | 3.3 | 7.5 | 103.0 | 76 | 34 | 30 | 9 | 38 | 86 | 0 | 9 | 3 | 0 | 0 | 1 | 1 | 3.60 |
| RP | Davis, W.Davis, Wade # >> | 29 | 2015 | R | 89 | 68 | 0 | 6 | 3 | 4.20 | .312 | 1.33 | 7.7 | 4.3 | 9.2 | 83.2 | 71 | 43 | 39 | 10 | 40 | 85 | 0 | 5 | 1 | 0 | 0 | 3 | 1 | 4.07 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 57 | 0 | 5 | 7 | 4.41 | .318 | 1.38 | 9.9 | 2.6 | 6.6 | 67.1 | 74 | 39 | 33 | 10 | 19 | 49 | 0 | 8 | 3 | 0 | 0 | 1 | 0 | 4.37 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 46 | 0 | 1 | 1 | 4.73 | .322 | 1.42 | 9.2 | 3.7 | 6.9 | 51.1 | 52 | 27 | 27 | 9 | 21 | 39 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 5.00 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 63 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |