| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 7 | 7 | 4 | 1 | 4.81 | .335 | 1.49 | 8.8 | 4.6 | 6.3 | 43.0 | 42 | 23 | 23 | 4 | 22 | 30 | 1 | 0 | 0 | 0 | 4 | 1 | 1 | 4.42 |
| SP | Snell, B.Snell, Blake # >> | 25 | 2018 | L | 81 | 7 | 7 | 3 | 3 | 5.89 | .349 | 1.58 | 9.3 | 5.3 | 7.8 | 36.2 | 37 | 26 | 24 | 7 | 21 | 31 | 0 | 0 | 0 | 0 | 2 | 1 | 2 | 5.64 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 8 | 7 | 3 | 1 | 5.62 | .335 | 1.51 | 10.1 | 3.7 | 7.7 | 41.2 | 46 | 27 | 26 | 4 | 17 | 35 | 2 | 0 | 0 | 0 | 2 | 0 | 1 | 3.80 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 20 | 0 | 1 | 0 | 1.36 | .202 | 0.76 | 4.9 | 1.9 | 12.0 | 33.0 | 18 | 5 | 5 | 1 | 7 | 44 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1.36 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 16 | 0 | 1 | 1 | 4.82 | .349 | 1.61 | 8.0 | 7.0 | 12.0 | 18.2 | 16 | 10 | 10 | 3 | 14 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.83 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 15 | 0 | 1 | 0 | 4.58 | .280 | 1.17 | 8.5 | 2.4 | 7.6 | 19.2 | 18 | 10 | 10 | 2 | 5 | 16 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 3.47 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 12 | 0 | 2 | 1 | 2.33 | .183 | 0.67 | 5.2 | 0.9 | 3.8 | 19.1 | 11 | 7 | 5 | 3 | 2 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.53 |