| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 4 | 4 | 0 | 3 | 9.00 | .364 | 1.71 | 12.4 | 3.0 | 6.4 | 21.0 | 29 | 21 | 21 | 4 | 7 | 15 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 5.05 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 3 | 3 | 0 | 0 | 2.74 | .281 | 1.13 | 6.7 | 3.5 | 9.4 | 23.0 | 17 | 7 | 7 | 3 | 9 | 24 | 0 | 0 | 0 | 0 | 3 | 1 | 1 | 3.91 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 6 | 0 | 0 | 1 | 3.86 | .300 | 1.14 | 10.3 | 0.0 | 7.7 | 7.0 | 8 | 3 | 3 | 1 | 0 | 6 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.57 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 5 | 0 | 0 | 1 | 6.23 | .278 | 1.15 | 9.0 | 2.3 | 9.0 | 4.1 | 4 | 3 | 3 | 1 | 1 | 4 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 5.00 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 11 | 0 | 0 | 3 | 10.61 | .391 | 1.93 | 12.0 | 6.0 | 5.0 | 9.1 | 12 | 11 | 11 | 4 | 6 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 9.67 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 7 | 0 | 1 | 0 | 2.16 | .286 | 1.20 | 7.9 | 3.4 | 11.3 | 8.1 | 7 | 2 | 2 | 2 | 3 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.88 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 67 | 7 | 0 | 2 | 0 | 3.12 | .333 | 1.38 | 11.3 | 2.3 | 5.6 | 8.2 | 10 | 3 | 3 | 2 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.13 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 84 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 5 | 0 | 0 | 0 | 0.00 | .161 | 0.58 | 4.5 | 1.1 | 4.5 | 8.2 | 4 | 0 | 0 | 0 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.38 |