| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 25 | 25 | 7 | 11 | 3.61 | .286 | 1.19 | 8.2 | 2.5 | 7.2 | 167.0 | 152 | 75 | 67 | 18 | 47 | 133 | 2 | 0 | 0 | 0 | 17 | 2 | 2 | 3.69 |
| SP | Snell, B.Snell, Blake † >> | 25 | 2018 | L | 81 | 24 | 24 | 11 | 7 | 2.95 | .263 | 1.06 | 6.2 | 3.4 | 7.3 | 152.1 | 104 | 51 | 50 | 11 | 58 | 124 | 1 | 0 | 0 | 1 | 16 | 1 | 5 | 3.47 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 24 | 24 | 10 | 5 | 4.34 | .268 | 1.09 | 8.3 | 1.5 | 5.9 | 163.2 | 150 | 87 | 79 | 22 | 28 | 107 | 4 | 0 | 0 | 0 | 10 | 2 | 0 | 3.99 |
| SP | Reulbach, E.Reulbach, Ed † >> | 24 | 1906 | R | 60 | 23 | 23 | 11 | 4 | 2.88 | .269 | 1.07 | 6.0 | 3.6 | 4.5 | 159.1 | 106 | 55 | 51 | 12 | 64 | 79 | 3 | 0 | 0 | 2 | 16 | 6 | 2 | 4.31 |
| RP | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 85 | 77 | 0 | 10 | 4 | 3.95 | .292 | 1.22 | 9.2 | 1.9 | 8.7 | 86.2 | 88 | 43 | 38 | 9 | 18 | 83 | 0 | 5 | 2 | 0 | 0 | 1 | 3 | 3.09 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 53 | 0 | 6 | 2 | 3.30 | .286 | 1.18 | 6.2 | 4.5 | 8.9 | 60.0 | 41 | 24 | 22 | 5 | 30 | 59 | 0 | 1 | 5 | 0 | 0 | 1 | 0 | 3.67 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 44 | 0 | 3 | 4 | 4.62 | .315 | 1.36 | 7.3 | 5.1 | 9.6 | 48.2 | 39 | 27 | 25 | 9 | 27 | 51 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 5.06 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 40 | 0 | 5 | 1 | 2.63 | .276 | 1.13 | 5.4 | 4.7 | 5.6 | 48.0 | 29 | 17 | 14 | 5 | 25 | 30 | 0 | 4 | 1 | 0 | 0 | 1 | 0 | 4.73 |
| CL | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 51 | 0 | 3 | 3 | 2.36 | .307 | 1.31 | 6.5 | 5.3 | 9.3 | 61.0 | 44 | 19 | 16 | 5 | 36 | 63 | 0 | 25 | 2 | 0 | 0 | 1 | 0 | 3.82 |