| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 24 | 24 | 10 | 8 | 3.67 | .278 | 1.14 | 7.8 | 2.4 | 9.1 | 162.0 | 141 | 70 | 66 | 18 | 44 | 164 | 2 | 0 | 0 | 1 | 16 | 2 | 0 | 3.27 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 24 | 24 | 10 | 9 | 4.19 | .288 | 1.18 | 8.0 | 2.7 | 7.8 | 171.2 | 152 | 84 | 80 | 22 | 51 | 149 | 3 | 0 | 0 | 0 | 14 | 5 | 3 | 3.91 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 61 | 0 | 5 | 3 | 3.15 | .279 | 1.11 | 7.4 | 2.6 | 8.7 | 80.0 | 66 | 30 | 28 | 11 | 23 | 77 | 0 | 10 | 2 | 0 | 0 | 4 | 2 | 3.88 |
| RP | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 87 | 49 | 0 | 6 | 3 | 2.25 | .253 | 1.00 | 6.3 | 2.7 | 8.2 | 56.0 | 39 | 16 | 14 | 3 | 17 | 51 | 0 | 7 | 2 | 0 | 0 | 1 | 0 | 2.84 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 19 | 0 | 1 | 0 | 2.70 | .302 | 1.30 | 5.0 | 6.8 | 7.7 | 20.0 | 11 | 6 | 6 | 1 | 15 | 17 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 4.20 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 1 | 1 | 0 | 0 | 3.86 | .160 | 0.43 | 3.9 | 0.0 | 9.0 | 7.0 | 3 | 3 | 3 | 2 | 0 | 7 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 5.14 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 55 | 1 | 0 | 0 | 0 | 0.00 | .333 | 1.50 | - | - | - | 0.2 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | - |