| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 31 | 31 | 11 | 11 | 4.15 | .296 | 1.24 | 8.7 | 2.5 | 6.2 | 188.2 | 181 | 105 | 87 | 22 | 53 | 129 | 6 | 0 | 0 | 1 | 16 | 4 | 3 | 4.06 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 49 | 29 | 28 | 12 | 9 | 4.69 | .328 | 1.45 | 10.5 | 2.6 | 7.3 | 134.1 | 157 | 81 | 70 | 17 | 38 | 108 | 0 | 0 | 0 | 0 | 11 | 2 | 2 | 3.93 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 82 | 0 | 10 | 3 | 2.83 | .288 | 1.21 | 6.7 | 4.2 | 10.1 | 121.0 | 90 | 40 | 38 | 14 | 56 | 136 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 3.67 |
| RP | Saito, T.Saito, Takashi † >> | 37 | 2007 | R | 91 | 88 | 0 | 5 | 3 | 3.65 | .273 | 1.10 | 6.6 | 3.3 | 8.8 | 111.0 | 81 | 49 | 45 | 10 | 41 | 109 | 0 | 2 | 4 | 0 | 0 | 3 | 0 | 3.40 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 74 | 0 | 5 | 4 | 5.08 | .321 | 1.40 | 8.0 | 4.7 | 10.7 | 83.1 | 74 | 53 | 47 | 11 | 43 | 99 | 0 | 11 | 3 | 0 | 0 | 1 | 2 | 3.93 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 61 | 0 | 4 | 1 | 4.09 | .315 | 1.35 | 8.7 | 3.5 | 7.6 | 70.1 | 68 | 34 | 32 | 12 | 27 | 59 | 0 | 6 | 6 | 0 | 0 | 2 | 5 | 4.79 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 46 | 0 | 3 | 7 | 7.99 | .393 | 1.88 | 11.7 | 5.4 | 8.6 | 47.1 | 61 | 45 | 42 | 12 | 28 | 45 | 0 | 2 | 5 | 0 | 0 | 3 | 0 | 6.38 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 38 | 0 | 2 | 3 | 6.45 | .376 | 1.75 | 9.7 | 6.3 | 9.5 | 37.2 | 40 | 28 | 27 | 8 | 26 | 39 | 0 | 4 | 1 | 0 | 0 | 2 | 3 | 5.97 |