| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 31 | 31 | 15 | 12 | 3.18 | .277 | 1.13 | 6.9 | 3.3 | 6.9 | 218.0 | 166 | 83 | 77 | 19 | 81 | 167 | 8 | 0 | 0 | 5 | 19 | 4 | 3 | 3.77 |
| SP | Leonard, D.Leonard, Dutch † $ >> | 22 | 1914 | L | 91 | 30 | 30 | 17 | 9 | 3.05 | .252 | 1.00 | 6.0 | 3.0 | 5.3 | 212.1 | 142 | 79 | 72 | 19 | 70 | 125 | 3 | 0 | 0 | 1 | 21 | 3 | 2 | 4.02 |
| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 82 | 30 | 30 | 16 | 6 | 3.10 | .252 | 1.00 | 7.0 | 2.0 | 4.3 | 221.0 | 171 | 76 | 76 | 19 | 49 | 105 | 7 | 0 | 0 | 4 | 19 | 3 | 3 | 3.87 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 67 | 8 | 8 | 4 | 3 | 3.23 | .303 | 1.27 | 8.3 | 3.2 | 6.5 | 61.1 | 56 | 23 | 22 | 6 | 22 | 44 | 0 | 0 | 0 | 0 | 5 | 2 | 1 | 4.02 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 63 | 0 | 2 | 1 | 3.21 | .295 | 1.26 | 7.3 | 4.1 | 10.4 | 53.1 | 43 | 19 | 19 | 4 | 24 | 61 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 3.04 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 71 | 0 | 4 | 3 | 2.05 | .272 | 1.12 | 5.6 | 4.5 | 9.0 | 66.0 | 41 | 15 | 15 | 4 | 33 | 66 | 0 | 3 | 3 | 0 | 0 | 0 | 1 | 3.29 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 82 | 49 | 0 | 4 | 2 | 3.27 | .303 | 1.31 | 8.1 | 3.7 | 6.6 | 41.1 | 37 | 17 | 15 | 6 | 17 | 30 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.68 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 18 | 0 | 3 | 2 | 1.96 | .360 | 1.69 | 12.5 | 3.0 | 6.0 | 18.1 | 25 | 4 | 4 | 1 | 6 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.39 |
| CL | Chapman, A.Chapman, Aroldis † >> | 37 | 2025 | L | 96 | 52 | 0 | 0 | 1 | 3.79 | .275 | 1.12 | 7.4 | 2.7 | 10.1 | 40.1 | 33 | 17 | 17 | 5 | 12 | 45 | 0 | 36 | 4 | 0 | 0 | 1 | 5 | 3.35 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 11 | 1 | 4 | 0 | 2.79 | .264 | 1.06 | 6.0 | 3.6 | 5.1 | 48.1 | 32 | 17 | 15 | 4 | 19 | 27 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.21 |