| SP | Martinez, P.Martinez, Pedro >> | 35 | 2006 | R | 97 | 36 | 36 | 13 | 15 | 4.36 | .318 | 1.38 | 9.2 | 3.3 | 7.8 | 221.0 | 226 | 111 | 107 | 16 | 80 | 192 | 0 | 0 | 0 | 0 | 20 | 3 | 7 | 3.33 |
| SP | Peavy, J.Peavy, Jake † # >> | 31 | 2012 | R | 93 | 35 | 35 | 15 | 10 | 3.49 | .270 | 1.09 | 7.8 | 2.0 | 6.1 | 255.2 | 220 | 104 | 99 | 21 | 58 | 172 | 7 | 0 | 0 | 3 | 23 | 6 | 2 | 3.47 |
| SP | Buehrle, M.Buehrle, Mark >> | 28 | 2007 | L | 61 | 32 | 31 | 9 | 15 | 5.73 | .343 | 1.54 | 11.2 | 2.8 | 5.6 | 205.2 | 254 | 142 | 131 | 21 | 63 | 127 | 1 | 0 | 0 | 0 | 12 | 5 | 6 | 4.09 |
| RP | Hodge, P.Hodge, Porter † >> | 23 | 2024 | R | 97 | 84 | 0 | 12 | 2 | 2.70 | .292 | 1.22 | 6.1 | 4.9 | 8.5 | 113.1 | 77 | 34 | 34 | 7 | 61 | 107 | 0 | 7 | 2 | 0 | 0 | 2 | 0 | 3.58 |
| RP | Osuna, A.Osuna, Antonio >> | 24 | 1997 | R | 88 | 89 | 0 | 3 | 6 | 2.76 | .275 | 1.12 | 7.3 | 2.8 | 8.4 | 127.1 | 103 | 44 | 39 | 12 | 40 | 119 | 0 | 13 | 7 | 0 | 0 | 2 | 6 | 3.35 |
| RP | Kahnle, T.Kahnle, Tommy # >> | 27 | 2017 | R | 75 | 70 | 0 | 6 | 4 | 4.08 | .312 | 1.33 | 8.8 | 3.3 | 9.2 | 81.2 | 79 | 38 | 37 | 6 | 30 | 83 | 0 | 5 | 3 | 0 | 0 | 2 | 5 | 3.10 |
| RP | Nitkowski, C.Nitkowski, C.J. >> | 25 | 1998 | L | 56 | 51 | 0 | 8 | 5 | 2.85 | .297 | 1.24 | 7.4 | 3.8 | 6.1 | 66.1 | 54 | 24 | 21 | 4 | 28 | 45 | 0 | 10 | 0 | 0 | 0 | 2 | 3 | 3.79 |
| RP | Wagner, G.Wagner, Gary >> | 28 | 1968 | R | 42 | 47 | 0 | 3 | 3 | 3.54 | .307 | 1.33 | 6.6 | 5.3 | 5.6 | 61.0 | 45 | 24 | 24 | 3 | 36 | 38 | 0 | 6 | 1 | 0 | 0 | 0 | 1 | 4.16 |
| RP | Doolittle, S.Doolittle, Sean >> | 32 | 2019 | L | 35 | 29 | 0 | 1 | 0 | 1.30 | .288 | 1.13 | 7.4 | 2.9 | 10.6 | 34.2 | 28 | 7 | 5 | 0 | 11 | 40 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 1.88 |