| SP | Martinez, P.Martinez, Pedro >> | 35 | 2006 | R | 97 | 8 | 8 | 3 | 3 | 5.36 | .332 | 1.47 | 9.6 | 3.6 | 8.8 | 47.0 | 50 | 29 | 28 | 3 | 19 | 46 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 3.15 |
| SP | Peavy, J.Peavy, Jake # >> | 31 | 2012 | R | 93 | 8 | 8 | 3 | 2 | 3.15 | .274 | 1.08 | 8.0 | 1.8 | 4.8 | 60.0 | 53 | 21 | 21 | 4 | 12 | 32 | 3 | 0 | 0 | 2 | 6 | 3 | 0 | 3.55 |
| SP | Buehrle, M.Buehrle, Mark >> | 28 | 2007 | L | 61 | 9 | 8 | 0 | 6 | 6.66 | .378 | 1.80 | 13.0 | 3.2 | 4.3 | 50.0 | 72 | 45 | 37 | 6 | 18 | 24 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 4.74 |
| RP | Hodge, P.Hodge, Porter >> | 23 | 2024 | R | 97 | 20 | 0 | 2 | 0 | 2.70 | .274 | 1.10 | 5.7 | 4.2 | 7.5 | 30.0 | 19 | 9 | 9 | 1 | 14 | 25 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.27 |
| RP | Osuna, A.Osuna, Antonio >> | 24 | 1997 | R | 88 | 20 | 0 | 1 | 0 | 2.67 | .235 | 0.86 | 6.5 | 1.4 | 8.7 | 33.2 | 24 | 10 | 10 | 5 | 5 | 32 | 0 | 3 | 1 | 0 | 0 | 2 | 1 | 3.67 |
| RP | Kahnle, T.Kahnle, Tommy >> | 27 | 2017 | R | 75 | 21 | 0 | 3 | 1 | 3.09 | .278 | 1.16 | 7.4 | 3.1 | 9.0 | 23.1 | 19 | 8 | 8 | 1 | 8 | 23 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 2.61 |
| RP | Nitkowski, C.Nitkowski, C.J. >> | 25 | 1998 | L | 56 | 10 | 0 | 2 | 1 | 1.26 | .271 | 1.12 | 5.1 | 5.1 | 6.4 | 14.1 | 8 | 4 | 2 | 0 | 8 | 10 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 3.29 |
| RP | Wagner, G.Wagner, Gary >> | 28 | 1968 | R | 42 | 10 | 0 | 1 | 2 | 5.51 | .310 | 1.35 | 10.1 | 2.3 | 5.6 | 16.1 | 18 | 10 | 10 | 3 | 4 | 10 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 4.94 |
| RP | Doolittle, S.Doolittle, Sean >> | 32 | 2019 | L | 35 | 8 | 0 | 1 | 0 | 0.93 | .293 | 1.14 | 6.0 | 5.0 | 9.0 | 9.2 | 6 | 1 | 1 | 0 | 5 | 9 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.00 |