| SP | Kluber, C.Kluber, Corey † >> | 31 | 2017 | R | 96 | 27 | 27 | 12 | 9 | 3.66 | .299 | 1.26 | 8.5 | 2.9 | 10.5 | 191.2 | 181 | 83 | 78 | 20 | 61 | 223 | 2 | 0 | 0 | 1 | 19 | 3 | 8 | 3.03 |
| SP | Lester, J.Lester, Jon # >> | 32 | 2016 | L | 78 | 27 | 27 | 10 | 9 | 4.35 | .315 | 1.32 | 9.6 | 2.3 | 8.4 | 180.0 | 192 | 91 | 87 | 29 | 45 | 168 | 1 | 0 | 0 | 1 | 14 | 11 | 2 | 4.16 |
| SP | Lackey, J.Lackey, John >> | 38 | 2016 | R | 60 | 26 | 26 | 6 | 10 | 5.79 | .348 | 1.58 | 10.7 | 3.6 | 7.7 | 155.1 | 184 | 102 | 100 | 40 | 62 | 132 | 0 | 0 | 0 | 0 | 7 | 3 | 2 | 5.91 |
| SP | Porcello, R.Porcello, Rick >> | 27 | 2016 | R | 56 | 26 | 26 | 7 | 14 | 5.80 | .333 | 1.46 | 10.4 | 2.8 | 7.5 | 153.2 | 177 | 103 | 99 | 27 | 47 | 127 | 2 | 0 | 0 | 0 | 11 | 6 | 2 | 4.67 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 76 | 0 | 3 | 4 | 3.48 | .264 | 1.05 | 6.9 | 2.6 | 10.7 | 103.1 | 79 | 41 | 40 | 14 | 30 | 122 | 0 | 6 | 5 | 0 | 0 | 2 | 4 | 3.33 |
| RP | Gregerson, L.Gregerson, Luke † >> | 26 | 2010 | R | 74 | 66 | 0 | 9 | 2 | 3.95 | .297 | 1.24 | 7.6 | 3.6 | 10.7 | 79.2 | 67 | 35 | 35 | 14 | 32 | 94 | 0 | 9 | 4 | 0 | 0 | 2 | 0 | 4.22 |
| RP | Workman, B.Workman, Brandon # >> | 30 | 2019 | R | 57 | 54 | 0 | 3 | 2 | 5.16 | .332 | 1.44 | 6.9 | 6.0 | 11.5 | 61.0 | 47 | 39 | 35 | 10 | 41 | 78 | 0 | 9 | 6 | 0 | 0 | 3 | 0 | 4.74 |
| SP | Mikolas, M.Mikolas, Miles >> | 29 | 2018 | R | 33 | 8 | 0 | 0 | 2 | 10.54 | .446 | 2.34 | 18.7 | 3.5 | 6.2 | 13.2 | 27 | 16 | 16 | 3 | 5 | 9 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 6.00 |
| SP | Halladay, R.Halladay, Roy >> | 33 | 2010 | R | 44 | 24 | 0 | 3 | 6 | 7.15 | .376 | 1.76 | 12.4 | 3.6 | 8.4 | 45.1 | 62 | 37 | 36 | 8 | 18 | 42 | 0 | 4 | 1 | 0 | 0 | 2 | 1 | 4.78 |