| SP | Kluber, C.Kluber, Corey † >> | 31 | 2017 | R | 95 | 36 | 36 | 13 | 14 | 3.33 | .278 | 1.13 | 7.7 | 2.5 | 8.8 | 240.1 | 205 | 92 | 89 | 34 | 66 | 234 | 6 | 0 | 0 | 5 | 21 | 6 | 5 | 3.79 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 90 | 35 | 35 | 14 | 14 | 4.36 | .292 | 1.21 | 8.7 | 2.2 | 7.2 | 229.1 | 222 | 118 | 111 | 28 | 56 | 182 | 9 | 0 | 0 | 2 | 17 | 6 | 6 | 3.81 |
| SP | Strider, S.Strider, Spencer >> | 23 | 2022 | R | 80 | 33 | 33 | 8 | 10 | 4.36 | .313 | 1.34 | 8.3 | 3.8 | 10.2 | 144.1 | 132 | 75 | 70 | 18 | 61 | 163 | 0 | 0 | 0 | 0 | 1 | 4 | 4 | 3.72 |
| SP | Harvey, M.Harvey, Matt † >> | 24 | 2013 | R | 76 | 33 | 33 | 13 | 11 | 3.64 | .290 | 1.21 | 8.0 | 2.9 | 8.9 | 207.2 | 185 | 84 | 84 | 21 | 66 | 204 | 0 | 0 | 0 | 0 | 23 | 3 | 4 | 3.35 |
| RP | Benoit, J.Benoit, Joaquin † >> | 33 | 2010 | R | 94 | 95 | 0 | 8 | 2 | 2.77 | .272 | 1.10 | 7.5 | 2.5 | 9.0 | 136.2 | 113 | 42 | 42 | 14 | 38 | 136 | 0 | 8 | 6 | 0 | 0 | 2 | 0 | 3.22 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 79 | 89 | 0 | 2 | 4 | 3.67 | .293 | 1.21 | 6.8 | 4.1 | 9.4 | 108.0 | 82 | 46 | 44 | 9 | 49 | 113 | 0 | 9 | 3 | 0 | 0 | 3 | 0 | 3.44 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 76 | 0 | 8 | 7 | 4.33 | .302 | 1.24 | 8.7 | 2.6 | 8.8 | 95.2 | 92 | 48 | 46 | 18 | 27 | 93 | 0 | 7 | 4 | 0 | 0 | 5 | 0 | 4.52 |
| RP | Balfour, G.Balfour, Grant # >> | 31 | 2008 | R | 74 | 57 | 0 | 5 | 2 | 4.28 | .283 | 1.17 | 6.4 | 4.2 | 8.3 | 69.1 | 49 | 33 | 33 | 12 | 32 | 64 | 0 | 6 | 2 | 0 | 0 | 1 | 0 | 4.84 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 73 | 38 | 0 | 3 | 4 | 5.11 | .323 | 1.39 | 9.0 | 3.5 | 10.4 | 44.0 | 44 | 25 | 25 | 7 | 17 | 51 | 0 | 1 | 1 | 0 | 0 | 2 | 2 | 4.05 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 62 | 37 | 0 | 1 | 0 | 3.57 | .328 | 1.41 | 6.8 | 6.1 | 9.2 | 40.1 | 30 | 19 | 16 | 4 | 27 | 41 | 0 | 3 | 0 | 0 | 0 | 2 | 3 | 4.43 |