| SP | Hudson, D.Hudson, Daniel # >> | 23 | 2010 | R | 72 | 33 | 33 | 8 | 15 | 5.40 | .329 | 1.46 | 9.4 | 3.8 | 6.2 | 198.1 | 206 | 121 | 119 | 37 | 83 | 136 | 0 | 0 | 0 | 0 | 13 | 3 | 7 | 5.36 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 32 | 32 | 12 | 13 | 4.97 | .306 | 1.31 | 9.7 | 2.1 | 8.0 | 235.1 | 254 | 142 | 130 | 49 | 54 | 210 | 4 | 0 | 0 | 1 | 10 | 4 | 3 | 4.66 |
| SP | Valenzuela, F.Valenzuela, Fernando # >> | 21 | 1981 | L | 61 | 32 | 32 | 12 | 12 | 6.11 | .343 | 1.53 | 10.1 | 3.7 | 8.3 | 206.1 | 231 | 143 | 140 | 35 | 84 | 191 | 1 | 0 | 0 | 0 | 11 | 8 | 5 | 4.69 |
| SP | DeLeon, J.DeLeon, Jose >> | 29 | 1989 | R | 60 | 31 | 31 | 8 | 11 | 6.10 | .345 | 1.54 | 9.5 | 4.4 | 6.5 | 189.0 | 200 | 133 | 128 | 36 | 92 | 137 | 0 | 0 | 0 | 0 | 9 | 7 | 2 | 5.60 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 85 | 0 | 9 | 6 | 3.91 | .303 | 1.26 | 7.8 | 3.7 | 11.0 | 103.2 | 89 | 49 | 45 | 12 | 42 | 126 | 0 | 8 | 6 | 0 | 0 | 4 | 3 | 3.41 |
| RP | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 84 | 82 | 0 | 8 | 3 | 3.03 | .260 | 1.02 | 7.4 | 1.7 | 8.6 | 110.0 | 91 | 37 | 37 | 12 | 21 | 105 | 0 | 9 | 2 | 0 | 0 | 4 | 3 | 3.19 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 66 | 66 | 0 | 5 | 4 | 3.53 | .299 | 1.23 | 6.9 | 4.1 | 9.8 | 79.0 | 61 | 31 | 31 | 13 | 36 | 86 | 0 | 11 | 3 | 0 | 0 | 4 | 2 | 4.48 |
| SP | Weaver, J.Weaver, Jered >> | 29 | 2011 | R | 54 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Norris, M.Norris, Mike >> | 25 | 1980 | R | 47 | 16 | 0 | 0 | 4 | 6.26 | .330 | 1.43 | 8.2 | 4.7 | 3.9 | 23.0 | 21 | 16 | 16 | 6 | 12 | 10 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 7.22 |