| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 36 | 36 | 16 | 15 | 3.78 | .298 | 1.23 | 8.7 | 2.4 | 10.0 | 252.1 | 243 | 116 | 106 | 27 | 67 | 280 | 9 | 0 | 0 | 2 | 19 | 12 | 3 | 3.11 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 90 | 33 | 33 | 17 | 8 | 3.76 | .280 | 1.16 | 8.6 | 1.8 | 9.4 | 225.0 | 214 | 98 | 94 | 28 | 46 | 234 | 3 | 0 | 0 | 3 | 18 | 2 | 4 | 3.18 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 53 | 33 | 33 | 13 | 12 | 4.11 | .318 | 1.37 | 7.7 | 4.7 | 9.5 | 201.1 | 172 | 99 | 92 | 19 | 104 | 212 | 2 | 0 | 0 | 1 | 19 | 5 | 3 | 3.75 |
| SP | Buehler, W.Buehler, Walker >> | 23 | 2018 | R | 84 | 31 | 31 | 8 | 14 | 5.76 | .352 | 1.61 | 10.7 | 3.8 | 8.7 | 147.0 | 175 | 98 | 94 | 24 | 62 | 142 | 1 | 0 | 0 | 0 | 13 | 3 | 4 | 4.52 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 86 | 0 | 2 | 3 | 2.47 | .258 | 1.04 | 7.0 | 2.4 | 9.6 | 116.2 | 90 | 32 | 32 | 12 | 31 | 124 | 0 | 6 | 2 | 0 | 0 | 1 | 2 | 3.03 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 73 | 75 | 0 | 8 | 3 | 4.52 | .314 | 1.34 | 7.6 | 4.6 | 11.0 | 83.2 | 70 | 45 | 42 | 14 | 42 | 101 | 0 | 6 | 4 | 0 | 0 | 3 | 5 | 4.39 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 67 | 65 | 0 | 4 | 0 | 3.44 | .333 | 1.47 | 7.5 | 5.9 | 9.0 | 70.2 | 58 | 32 | 27 | 10 | 46 | 70 | 0 | 6 | 2 | 0 | 0 | 2 | 5 | 4.91 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 46 | 0 | 2 | 2 | 3.83 | .315 | 1.36 | 9.0 | 3.3 | 8.3 | 49.1 | 49 | 21 | 21 | 5 | 18 | 45 | 0 | 9 | 2 | 0 | 0 | 1 | 2 | 3.65 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 27 | 0 | 3 | 5 | 4.73 | .339 | 1.54 | 7.6 | 6.6 | 9.3 | 26.2 | 22 | 15 | 14 | 2 | 19 | 27 | 0 | 4 | 2 | 0 | 0 | 0 | 0 | 4.12 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 78 | 29 | 0 | 0 | 2 | 3.45 | .333 | 1.43 | 6.4 | 6.8 | 10.6 | 28.2 | 20 | 12 | 11 | 1 | 21 | 33 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 3.57 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 80 | 35 | 0 | 1 | 1 | 3.92 | .311 | 1.35 | 6.9 | 5.4 | 7.7 | 43.2 | 33 | 23 | 19 | 7 | 26 | 37 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 5.21 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 77 | 16 | 0 | 1 | 1 | 6.15 | .350 | 1.55 | 11.5 | 2.5 | 9.8 | 71.2 | 91 | 54 | 49 | 9 | 20 | 77 | 0 | 0 | 0 | 0 | 0 | 5 | 2 | 3.54 |