| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 22 | 22 | 5 | 8 | 3.56 | .271 | 1.09 | 7.3 | 2.5 | 11.2 | 129.0 | 104 | 55 | 51 | 24 | 36 | 161 | 0 | 0 | 0 | 0 | 14 | 4 | 0 | 3.85 |
| SP | Harvey, M.Harvey, Matt >> | 24 | 2013 | R | 76 | 22 | 22 | 9 | 5 | 3.87 | .288 | 1.20 | 8.3 | 2.5 | 7.3 | 121.0 | 112 | 53 | 52 | 16 | 33 | 98 | 2 | 0 | 0 | 2 | 10 | 2 | 1 | 3.97 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 68 | 21 | 21 | 6 | 5 | 4.42 | .292 | 1.20 | 8.2 | 2.7 | 8.7 | 97.2 | 88 | 48 | 48 | 13 | 29 | 94 | 0 | 0 | 0 | 0 | 6 | 4 | 2 | 3.82 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 39 | 19 | 16 | 6 | 5 | 4.50 | .338 | 1.51 | 9.0 | 4.6 | 9.7 | 86.0 | 86 | 44 | 43 | 10 | 44 | 93 | 1 | 1 | 0 | 1 | 8 | 2 | 1 | 3.95 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 84 | 20 | 12 | 7 | 4 | 3.35 | .283 | 1.16 | 7.4 | 3.0 | 6.0 | 86.0 | 71 | 35 | 32 | 6 | 29 | 57 | 3 | 0 | 1 | 0 | 7 | 2 | 1 | 3.66 |
| RP | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 62 | 0 | 6 | 1 | 3.13 | .244 | 0.95 | 6.4 | 2.2 | 10.4 | 77.2 | 55 | 28 | 27 | 11 | 19 | 89 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 3.32 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 85 | 55 | 0 | 4 | 2 | 3.42 | .304 | 1.27 | 9.9 | 1.7 | 10.2 | 52.2 | 57 | 28 | 20 | 12 | 10 | 59 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 4.42 |
| RP | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 79 | 41 | 0 | 3 | 2 | 2.98 | .249 | 0.94 | 6.6 | 1.9 | 8.1 | 42.1 | 31 | 18 | 14 | 6 | 9 | 38 | 0 | 3 | 3 | 0 | 0 | 2 | 0 | 3.83 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 72 | 40 | 0 | 0 | 3 | 4.54 | .303 | 1.31 | 5.5 | 6.5 | 14.7 | 33.2 | 20 | 17 | 17 | 3 | 24 | 54 | 0 | 3 | 1 | 0 | 0 | 0 | 2 | 3.09 |
| SP | Hudson, T.Hudson, Tim # >> | 28 | 2003 | R | 27 | 18 | 12 | 7 | 6 | 3.98 | .280 | 1.16 | 8.0 | 2.4 | 6.3 | 81.1 | 72 | 38 | 36 | 13 | 22 | 57 | 1 | 0 | 0 | 0 | 4 | 1 | 1 | 4.53 |