| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 30 | 30 | 13 | 10 | 3.65 | .293 | 1.20 | 7.0 | 3.9 | 9.5 | 189.2 | 146 | 78 | 77 | 26 | 82 | 200 | 1 | 0 | 0 | 1 | 18 | 8 | 5 | 4.10 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 75 | 30 | 29 | 5 | 8 | 4.60 | .328 | 1.46 | 9.2 | 4.0 | 9.8 | 119.1 | 121 | 68 | 61 | 22 | 53 | 129 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 4.60 |
| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 65 | 28 | 28 | 8 | 14 | 5.55 | .328 | 1.45 | 11.0 | 2.0 | 9.5 | 167.0 | 204 | 105 | 103 | 35 | 38 | 177 | 5 | 0 | 0 | 1 | 11 | 2 | 1 | 4.32 |
| SP | Messersmith, A.Messersmith, Andy >> | 30 | 1975 | R | 43 | 28 | 27 | 9 | 10 | 5.09 | .331 | 1.47 | 9.7 | 3.6 | 5.6 | 162.2 | 174 | 101 | 92 | 30 | 65 | 100 | 4 | 0 | 0 | 0 | 11 | 2 | 3 | 5.41 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 92 | 0 | 7 | 2 | 3.81 | .275 | 1.12 | 6.1 | 4.1 | 11.4 | 120.1 | 81 | 54 | 51 | 12 | 54 | 152 | 0 | 5 | 1 | 0 | 0 | 2 | 9 | 3.17 |
| RP | Jackson, M.Jackson, Mike † >> | 30 | 1994 | R | 81 | 91 | 0 | 7 | 3 | 3.61 | .286 | 1.17 | 7.5 | 3.1 | 9.5 | 119.2 | 99 | 51 | 48 | 16 | 41 | 126 | 0 | 6 | 4 | 0 | 0 | 4 | 0 | 3.76 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 74 | 0 | 3 | 6 | 5.20 | .344 | 1.55 | 7.9 | 6.1 | 9.0 | 88.1 | 77 | 53 | 51 | 9 | 60 | 88 | 0 | 4 | 6 | 0 | 0 | 2 | 3 | 4.44 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 73 | 70 | 0 | 6 | 6 | 4.84 | .314 | 1.37 | 8.3 | 4.1 | 10.4 | 83.2 | 77 | 45 | 45 | 18 | 38 | 96 | 0 | 4 | 4 | 0 | 0 | 0 | 5 | 4.88 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 65 | 70 | 0 | 3 | 4 | 3.94 | .298 | 1.27 | 7.4 | 4.2 | 10.2 | 77.2 | 63 | 34 | 34 | 16 | 36 | 87 | 0 | 5 | 2 | 0 | 0 | 0 | 2 | 4.84 |